Reaction Details |
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Target | Histone deacetylase (HDAC1 and HDAC2) |
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Ligand | BDBM50221988 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_87403 (CHEMBL693167) |
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IC50 | >5±n/a nM |
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Citation | Wada, CK; Frey, RR; Ji, Z; Curtin, ML; Garland, RB; Holms, JH; Li, J; Pease, LJ; Guo, J; Glaser, KB; Marcotte, PA; Richardson, PL; Murphy, SS; Bouska, JJ; Tapang, P; Magoc, TJ; Albert, DH; Davidsen, SK; Michaelides, MR Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett13:3331-5 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase (HDAC1 and HDAC2) |
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Name: | Histone deacetylase (HDAC1 and HDAC2) |
Synonyms: | HDACs | Histone deacetylase 1/2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 2197604 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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Component 2 |
Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50221988 |
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n/a |
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Name | BDBM50221988 |
Synonyms: | CHEMBL113566 |
Type | Small organic molecule |
Emp. Form. | C22H27NO3 |
Mol. Mass. | 353.4547 |
SMILES | CN(C)C(=O)C(=O)CCCCCCOc1ccc(cc1)-c1ccccc1 |
Structure |
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