| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenylate cyclase type 1 |
|---|
| Ligand | BDBM50222266 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_31571 (CHEMBL644534) |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Kaiser, C; Ali, FE; Bondinell, WE; Brenner, M; Holden, KG; Ku, TW; Oh, HJ; Ross, ST; Yim, NC; Zirkle, CL; Hahn, RA; Sarau, HM; Setler, PE; Wardell, JR 6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics. J Med Chem23:975-6 (1980) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenylate cyclase type 1 |
|---|
| Name: | Adenylate cyclase type 1 |
|---|
| Synonyms: | 4.6.1.1 | Adcy1 | Adenylate cyclase | Synonyms=Adcy1_predicted |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 108287.66 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_104763 |
|---|
| Residue: | 967 |
|---|
| Sequence: | MGSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRT
LGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPR
NVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFG
KFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDL
NMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYE
VEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMH
CRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLL
EARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQ
SVAVLLLLVFSICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLIYSVAQGCVVS
CLPWAWSSHSNSSLVVLAAGGRRTVLPALPCESAHHGLLCCLVGTLPLAIFLRVSSLPKM
ILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDY
LWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFAS
IPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLA
PTAGTRAKKSISSHLSTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARR
PQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYF
LEGRTDGSSSHSRSLRLERRMFPYGRGGGGQARRPPLCPAAGPPIKPGLSPAPTSQYLSS
TAAGKEA
|
|
|
|---|
| BDBM50222266 |
|---|
| n/a |
|---|
| Name | BDBM50222266 |
|---|
| Synonyms: | CHEMBL369006 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18ClNO2S |
|---|
| Mol. Mass. | 335.848 |
|---|
| SMILES | CN1CCc2c(Cl)c(O)c(O)c(Sc3ccccc3)c2CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
