Reaction Details | |||
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Target | Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 | ||
Ligand | BDBM50000788 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_147640 (CHEMBL757324) | ||
IC50 | 150±n/a nM | ||
Citation | Kobylecki, RJ; Carling, RW; Lord, JA; Smith, CF; Lane, AC Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone. J Med Chem25:116-20 (1982) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 | |||
Name: | Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 | ||
Synonyms: | Opioid receptor | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of ChEMBL is 172778 | ||
Components: | This complex has 4 components. | ||
Component 1 | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44503.11 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. | ||
Residue: | 398 | ||
Sequence: |
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Component 2 | |||
Name: | Sigma non-opioid intracellular receptor 1 | ||
Synonyms: | Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 25266.54 | ||
Organism: | RAT | ||
Description: | Q9R0C9 | ||
Residue: | 223 | ||
Sequence: |
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Component 3 | |||
Name: | Kappa-type opioid receptor | ||
Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 42692.90 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | P34975 | ||
Residue: | 380 | ||
Sequence: |
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Component 4 | |||
Name: | Delta-type opioid receptor | ||
Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 40465.04 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. | ||
Residue: | 372 | ||
Sequence: |
| ||
BDBM50000788 | |||
n/a | |||
Name | BDBM50000788 | ||
Synonyms: | (morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol | (naloxone) 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one | (naloxone)4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one | (naloxone)4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one | 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one | 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one (naloxone) | 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one( Naloxone) | 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(Naxolone) | 4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one | 4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(naloxone)C2H2O4 | Analog of 14-(Arylhydroxyamino)codeinone | NALOXONE | NARCAN | SUBOXONE | [17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydroxymorphinan-6-one | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21NO4 | ||
Mol. Mass. | 327.3743 | ||
SMILES | Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| | ||
Structure |