| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50029760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_55072 (CHEMBL858271) |
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| Ki | 550±n/a nM |
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| Citation |  Hansch, C; Li, R; Blaney, JM; Langridge, R Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis. J Med Chem25:777-84 (1982) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_LACCA | dhfR | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18437.08 |
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| Organism: | Lactobacillus casei |
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| Description: | ChEMBL_1357878 |
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| Residue: | 163 |
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| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
|
|
|
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| BDBM50029760 |
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| n/a |
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| Name | BDBM50029760 |
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| Synonyms: | 5-[3,5-Dimethoxy-4-(2-methoxy-ethoxy)-benzyl]-pyrimidine-2,4-diamine | 5-[3,5-Dimethoxy-4-(2-methoxy-ethoxy)-benzyl]-pyrimidine-2,4-diamine(Tetroxoprim ) | CHEMBL32039 | Tetroxoprim |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N4O4 |
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| Mol. Mass. | 334.3703 |
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| SMILES | COCCOc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC |
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| Structure | 
|
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