| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-1/type-2 |
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| Ligand | BDBM50226770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_104956 (CHEMBL715638) |
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| Ki | 3000±n/a nM |
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| Citation |  Vrudhula, VM; Kappler, F; Hampton, A Isozyme-specific enzyme inhibitors. 13. S-[5'(R)-[(N-triphosphoamino)methyl]adenosyl]-L-homocysteine, a potent inhibitor of rat methionine adenosyltransferases. J Med Chem30:888-94 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase isoform type-1/type-2 |
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| Name: | S-adenosylmethionine synthase isoform type-1/type-2 |
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| Synonyms: | S-adenosylmethionine synthetase (MAT 1 and MAT 2) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 104961 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | S-adenosylmethionine synthase isoform type-1 |
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| Synonyms: | AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43692.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_11027 |
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| Residue: | 397 |
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| Sequence: | MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPD
SKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPG
VIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
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| Component 2 |
| Name: | S-adenosylmethionine synthase isoform type-2 |
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| Synonyms: | AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43713.68 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105118 |
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| Residue: | 395 |
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| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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| BDBM50226770 |
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| n/a |
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| Name | BDBM50226770 |
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| Synonyms: | CHEMBL609078 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H26N7O14P3S |
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| Mol. Mass. | 653.392 |
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| SMILES | [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r| |
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| Structure | 
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