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TargetEstrogen receptor beta
LigandBDBM50228276
Substrate/Competitorn/a
Meas. Tech.ChEMBL_66852 (CHEMBL680737)
EC50 2980±n/a nM
Citation Peters, RHCrowe, DFAvery, MAChong, WKTanabe, M 17-Desoxy estrogen analogues. J Med Chem32:1642-52 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Estrogen receptor beta
Name:Estrogen receptor beta
Synonyms:Estrogen receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 66549
Components:This complex has 2 components.
Component 1
Name:Estrogen receptor
Synonyms:ESR1_RAT | Esr | Esr1 | Estr | Nr3a1 | estrogen alpha
Type:Enzyme Catalytic Domain
Mol. Mass.:67045.89
Organism:RAT
Description:estrogen alpha 0 RAT::P06211
Residue:600
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAY
EFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPP
HVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMI
MESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRK
SCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSP
LVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQG
KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI
HRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVP
LYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI
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  Blast E-value cutoff:
Component 2
Name:Estrogen receptor beta
Synonyms:ESR2_RAT | Erbeta | Esr2 | Estrogen receptor | Estrogen receptor beta | Nr3a2
Type:PROTEIN
Mol. Mass.:59173.80
Organism:Rattus norvegicus
Description:ChEMBL_803011
Residue:530
Sequence:
MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPG
STSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVN
RETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVH
CLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTK
LADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEA
ESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ
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BDBM50228276
n/a
NameBDBM50228276
Synonyms:CHEMBL1627365
TypeSmall organic molecule
Emp. Form.C19H24O
Mol. Mass.268.3933
SMILES[H][C@@]12CCC(=C)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H] |r|
Structure
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