| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50013093 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208025 (CHEMBL814153) |
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| IC50 | 6918±n/a nM |
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| Citation |  Gambino, J; Focher, F; Hildebrand, C; Maga, G; Noonan, T; Spadari, S; Wright, G Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases. J Med Chem35:2979-83 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_HHV1S | TK | Thymidine kinase | UL23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40883.42 |
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| Organism: | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
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| Description: | ChEMBL_213 |
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| Residue: | 376 |
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| Sequence: | MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPT
ICDLARTFAREMGEAN
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|
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| BDBM50013093 |
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| n/a |
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| Name | BDBM50013093 |
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| Synonyms: | 2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin-6-one | CHEMBL16026 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15N5O |
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| Mol. Mass. | 269.3018 |
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| SMILES | CCc1cc(Nc2nc3nc[nH]c3c(=O)[nH]2)ccc1C |
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| Structure | 
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