| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D-3-phosphoglycerate dehydrogenase |
|---|
| Ligand | BDBM50230354 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1644827 (CHEMBL3993756) |
|---|
| IC50 | 35100±n/a nM |
|---|
| Citation |  Ravez, S; Corbet, C; Spillier, Q; Dutu, A; Robin, AD; Mullarky, E; Cantley, LC; Feron, O; Frédérick, R a-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). J Med Chem60:1591-1597 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D-3-phosphoglycerate dehydrogenase |
|---|
| Name: | D-3-phosphoglycerate dehydrogenase |
|---|
| Synonyms: | D-3-phosphoglycerate dehydrogenase | PGDH3 | PHGDH | Phosphoglycerate dehydrogenase (PHGDH) | SERA_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56650.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 533 |
|---|
| Sequence: | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
|
|
|
|---|
| BDBM50230354 |
|---|
| n/a |
|---|
| Name | BDBM50230354 |
|---|
| Synonyms: | CHEMBL4084694 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H12N2O4S |
|---|
| Mol. Mass. | 280.3 |
|---|
| SMILES | [O-][N+](=O)c1ccc(cc1)C(=O)C(=S)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
