| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Atrial natriuretic peptide receptor 1 |
|---|
| Ligand | BDBM50230982 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1645075 (CHEMBL3994004) |
|---|
| EC50 | 19±n/a nM |
|---|
| Citation |  Iwaki, T; Oyama, Y; Tomoo, T; Tanaka, T; Okamura, Y; Sugiyama, M; Yamaki, A; Furuya, M Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists. Bioorg Med Chem25:1762-1769 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Atrial natriuretic peptide receptor 1 |
|---|
| Name: | Atrial natriuretic peptide receptor 1 |
|---|
| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 118919.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_700223 |
|---|
| Residue: | 1061 |
|---|
| Sequence: | MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE
LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY
AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER
QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR
VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV
SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY
IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF
RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS
LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY
GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG
ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN
LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG
DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM
QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE
EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL
LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR
IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET
KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
|
|
|
|---|
| BDBM50230982 |
|---|
| n/a |
|---|
| Name | BDBM50230982 |
|---|
| Synonyms: | CHEMBL4097422 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H34F6N20O6 |
|---|
| Mol. Mass. | 872.7011 |
|---|
| SMILES | OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(C)C(=O)N=C3N)cc2)n1 |c:19,55| |
|---|
| Structure | 
|
|---|
Search and Browse
