Found 82 hits with Last Name = 'furuya' and Initial = 'm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230981
(CHEMBL4070239)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(C)C(=O)N=C3N)cc2)n1 |c:16,52| Show InChI InChI=1S/C22H26N20O2.2C2HF3O2/c1-7-11(43)31-15(27)41(7)21-37-17(35-19(39-21)33-13(23)24)29-9-3-5-10(6-4-9)30-18-36-20(34-14(25)26)40-22(38-18)42-8(2)12(44)32-16(42)28;2*3-2(4,5)1(6)7/h3-8H,1-2H3,(H2,27,31,43)(H2,28,32,44)(H5,23,24,29,33,35,37,39)(H5,25,26,30,34,36,38,40);2*(H,6,7) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230982
(CHEMBL4097422)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(C)C(=O)N=C3N)cc2)n1 |c:19,55| Show InChI InChI=1S/C25H32N20O2.2C2HF3O2/c1-9(2)8-13-15(47)35-19(31)45(13)25-41-21(39-23(43-25)37-17(28)29)33-12-6-4-11(5-7-12)32-20-38-22(36-16(26)27)42-24(40-20)44-10(3)14(46)34-18(44)30;2*3-2(4,5)1(6)7/h4-7,9-10,13H,8H2,1-3H3,(H2,30,34,46)(H2,31,35,47)(H5,26,27,32,36,38,40,42)(H5,28,29,33,37,39,41,43);2*(H,6,7) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230983
(CHEMBL4061575)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CC(C)C)C(=O)N=C3N)cc2)n1 |c:19,58| Show InChI InChI=1S/C28H38N20O2.2C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h5-8,11-12,15-16H,9-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230984
(CHEMBL4099832)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CCCC)C(=O)N=C3N)cc2)n1 |c:19,58| Show InChI InChI=1S/C28H38N20O2.2C2HF3O2/c1-3-5-7-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-9-11-14(12-10-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(8-6-4-2)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h9-12,15-16H,3-8H2,1-2H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230986
(Carperitide | SUN-4936)Show SMILES [H][C@]1(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230987
(CHEMBL4071293)Show SMILES C\N=C(/N(C)C)N(C)c1nc(Nc2ccccc2)nc(n1)N1C(CC(C)C)C(=O)N=C1N |c:31| Show InChI InChI=1S/C21H30N10O/c1-13(2)12-15-16(32)25-17(22)31(15)20-27-18(24-14-10-8-7-9-11-14)26-19(28-20)30(6)21(23-3)29(4)5/h7-11,13,15H,12H2,1-6H3,(H2,22,25,32)(H,24,26,27,28)/b23-21+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50230988
(CHEMBL4089697)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC2CCC(CC2)Nc2nc(NC(N)=N)nc(n2)N2C(CC(C)C)C(=O)N=C2N)nc(NC(N)=N)n1 |c:31,67,(32.04,-9.35,;30.7,-8.58,;30.71,-7.04,;29.37,-9.35,;28.16,-10.05,;27.86,-8.78,;29.11,-10.94,;34.89,-15.88,;33.55,-15.11,;33.56,-13.57,;32.22,-15.88,;31,-16.58,;30.71,-15.31,;31.96,-17.47,;14.68,-11.45,;13.34,-10.68,;13.35,-9.14,;12.01,-11.45,;10.8,-12.15,;10.5,-10.88,;11.75,-13.04,;17.66,-21.6,;16.32,-20.83,;16.33,-19.29,;14.99,-21.6,;13.77,-22.3,;13.48,-21.03,;14.73,-23.19,;25.36,-7.78,;23.88,-7.36,;23.51,-5.86,;22.77,-8.43,;21.29,-8,;20.07,-8.94,;18.8,-8.07,;17.35,-8.6,;19.23,-6.59,;20.77,-6.54,;21.63,-5.28,;20.12,-10.48,;21.48,-11.21,;21.52,-12.75,;22.88,-13.47,;22.93,-15.02,;21.62,-15.83,;21.66,-17.37,;23.03,-18.1,;24.33,-17.28,;24.28,-15.74,;23.07,-19.63,;24.42,-20.36,;25.74,-19.55,;27.09,-20.28,;28.4,-19.47,;29.76,-20.19,;29.8,-21.73,;31.07,-19.39,;27.14,-21.82,;25.83,-22.63,;24.47,-21.9,;25.88,-24.17,;24.66,-25.11,;23.18,-24.69,;22.07,-25.75,;20.59,-25.33,;22.44,-27.25,;25.18,-26.56,;24.32,-27.83,;26.72,-26.51,;27.15,-25.04,;28.6,-24.51,;20.21,-13.56,;18.85,-12.83,;17.55,-13.64,;17.6,-15.18,;18.95,-15.91,;16.29,-15.99,;18.81,-11.29,)| Show InChI InChI=1S/C28H44N20O2.4C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;4*3-2(4,5)1(6)7/h11-16H,5-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);4*(H,6,7) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 76 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50230984
(CHEMBL4099832)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(CCCC)C(=O)N=C3N)cc2)n1 |c:19,58| Show InChI InChI=1S/C28H38N20O2.2C2HF3O2/c1-3-5-7-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-9-11-14(12-10-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(8-6-4-2)18(50)38-22(48)34;2*3-2(4,5)1(6)7/h9-12,15-16H,3-8H2,1-2H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);2*(H,6,7) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230988
(CHEMBL4089697)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC2CCC(CC2)Nc2nc(NC(N)=N)nc(n2)N2C(CC(C)C)C(=O)N=C2N)nc(NC(N)=N)n1 |c:31,67,(32.04,-9.35,;30.7,-8.58,;30.71,-7.04,;29.37,-9.35,;28.16,-10.05,;27.86,-8.78,;29.11,-10.94,;34.89,-15.88,;33.55,-15.11,;33.56,-13.57,;32.22,-15.88,;31,-16.58,;30.71,-15.31,;31.96,-17.47,;14.68,-11.45,;13.34,-10.68,;13.35,-9.14,;12.01,-11.45,;10.8,-12.15,;10.5,-10.88,;11.75,-13.04,;17.66,-21.6,;16.32,-20.83,;16.33,-19.29,;14.99,-21.6,;13.77,-22.3,;13.48,-21.03,;14.73,-23.19,;25.36,-7.78,;23.88,-7.36,;23.51,-5.86,;22.77,-8.43,;21.29,-8,;20.07,-8.94,;18.8,-8.07,;17.35,-8.6,;19.23,-6.59,;20.77,-6.54,;21.63,-5.28,;20.12,-10.48,;21.48,-11.21,;21.52,-12.75,;22.88,-13.47,;22.93,-15.02,;21.62,-15.83,;21.66,-17.37,;23.03,-18.1,;24.33,-17.28,;24.28,-15.74,;23.07,-19.63,;24.42,-20.36,;25.74,-19.55,;27.09,-20.28,;28.4,-19.47,;29.76,-20.19,;29.8,-21.73,;31.07,-19.39,;27.14,-21.82,;25.83,-22.63,;24.47,-21.9,;25.88,-24.17,;24.66,-25.11,;23.18,-24.69,;22.07,-25.75,;20.59,-25.33,;22.44,-27.25,;25.18,-26.56,;24.32,-27.83,;26.72,-26.51,;27.15,-25.04,;28.6,-24.51,;20.21,-13.56,;18.85,-12.83,;17.55,-13.64,;17.6,-15.18,;18.95,-15.91,;16.29,-15.99,;18.81,-11.29,)| Show InChI InChI=1S/C28H44N20O2.4C2HF3O2/c1-11(2)9-15-17(49)37-21(33)47(15)27-43-23(41-25(45-27)39-19(29)30)35-13-5-7-14(8-6-13)36-24-42-26(40-20(31)32)46-28(44-24)48-16(10-12(3)4)18(50)38-22(48)34;4*3-2(4,5)1(6)7/h11-16H,5-10H2,1-4H3,(H2,33,37,49)(H2,34,38,50)(H5,29,30,35,39,41,43,45)(H5,31,32,36,40,42,44,46);4*(H,6,7) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50230989
(CHEMBL4092093)Show SMILES CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccccc2)n1 |c:7| Show InChI InChI=1S/C17H22N10O/c1-9(2)8-11-12(28)22-14(20)27(11)17-25-15(21-10-6-4-3-5-7-10)24-16(26-17)23-13(18)19/h3-7,9,11H,8H2,1-2H3,(H2,20,22,28)(H5,18,19,21,23,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50230986
(Carperitide | SUN-4936)Show SMILES [H][C@]1(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,99-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 1762-1769 (2017)
Article DOI: 10.1016/j.bmc.2017.01.026
BindingDB Entry DOI: 10.7270/Q2VX0JR5 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262427
(CHEMBL4060401)Show SMILES COc1cccc(c1)-c1ccc2nc(NC(C)C)nc(N[C@H]3CC[C@@H](CC3)NC(=O)C3CCCN(C)C3)c2c1 |r,wU:24.28,wD:21.21,(48.54,-18.83,;49.87,-18.06,;51.21,-18.82,;51.21,-20.36,;52.56,-21.13,;53.88,-20.36,;53.88,-18.82,;52.54,-18.05,;55.2,-18.05,;55.2,-16.5,;56.53,-15.74,;57.87,-16.51,;59.19,-15.73,;60.53,-16.5,;61.86,-15.72,;63.19,-16.49,;64.53,-15.71,;63.2,-18.03,;60.53,-18.05,;59.2,-18.82,;59.19,-20.36,;60.53,-21.13,;60.52,-22.67,;61.85,-23.44,;63.19,-22.67,;63.19,-21.13,;61.86,-20.35,;64.52,-23.45,;65.85,-22.68,;65.86,-21.14,;67.18,-23.46,;68.52,-22.69,;69.85,-23.47,;69.84,-25.02,;68.5,-25.77,;68.48,-27.31,;67.17,-25,;57.86,-18.05,;56.53,-18.82,)| Show InChI InChI=1S/C31H42N6O2/c1-20(2)32-31-35-28-15-10-22(21-7-5-9-26(17-21)39-4)18-27(28)29(36-31)33-24-11-13-25(14-12-24)34-30(38)23-8-6-16-37(3)19-23/h5,7,9-10,15,17-18,20,23-25H,6,8,11-14,16,19H2,1-4H3,(H,34,38)(H2,32,33,35,36)/t23?,24-,25- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262428
(CHEMBL4086092)Show SMILES CC(C)Nc1nc(NCc2ccccc2NC(=O)C2CCCN(C)C2)c2sc(cc2n1)-c1ccccc1 Show InChI InChI=1S/C29H34N6OS/c1-19(2)31-29-33-24-16-25(20-10-5-4-6-11-20)37-26(24)27(34-29)30-17-21-12-7-8-14-23(21)32-28(36)22-13-9-15-35(3)18-22/h4-8,10-12,14,16,19,22H,9,13,15,17-18H2,1-3H3,(H,32,36)(H2,30,31,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262429
(CHEMBL4064569)Show SMILES CC(C)Nc1nc(NCc2ccccc2NC(C)=O)c2sc(cc2n1)-c1ccccc1 Show InChI InChI=1S/C24H25N5OS/c1-15(2)26-24-28-20-13-21(17-9-5-4-6-10-17)31-22(20)23(29-24)25-14-18-11-7-8-12-19(18)27-16(3)30/h4-13,15H,14H2,1-3H3,(H,27,30)(H2,25,26,28,29) | PDB
MMDB
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262430
(CHEMBL4077657)Show SMILES CC(C)Nc1nc(NCc2cccc(NC(C)=O)c2)c2sc(cc2n1)-c1ccccc1 Show InChI InChI=1S/C24H25N5OS/c1-15(2)26-24-28-20-13-21(18-9-5-4-6-10-18)31-22(20)23(29-24)25-14-17-8-7-11-19(12-17)27-16(3)30/h4-13,15H,14H2,1-3H3,(H,27,30)(H2,25,26,28,29) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262431
(CHEMBL4085505)Show InChI InChI=1S/C21H21N5S/c1-14(2)24-21-25-17-12-18(15-8-4-3-5-9-15)27-19(17)20(26-21)23-13-16-10-6-7-11-22-16/h3-12,14H,13H2,1-2H3,(H2,23,24,25,26) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262432
(CHEMBL4103433)Show SMILES CC(C)CNc1nc(NCc2cccnc2)c2sc(cc2n1)-c1ccccc1 Show InChI InChI=1S/C22H23N5S/c1-15(2)12-25-22-26-18-11-19(17-8-4-3-5-9-17)28-20(18)21(27-22)24-14-16-7-6-10-23-13-16/h3-11,13,15H,12,14H2,1-2H3,(H2,24,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262433
(CHEMBL4093257)Show InChI InChI=1S/C21H21N5S/c1-14(2)24-21-25-17-11-18(16-8-4-3-5-9-16)27-19(17)20(26-21)23-13-15-7-6-10-22-12-15/h3-12,14H,13H2,1-2H3,(H2,23,24,25,26) | PDB
MMDB
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UniProtKB/SwissProt
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262434
(CHEMBL4086415)Show SMILES CC(C)Nc1nc(NCc2ccccc2NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccccc1 Show InChI InChI=1S/C31H36N6O/c1-21(2)33-31-35-28-16-15-23(22-10-5-4-6-11-22)18-26(28)29(36-31)32-19-24-12-7-8-14-27(24)34-30(38)25-13-9-17-37(3)20-25/h4-8,10-12,14-16,18,21,25H,9,13,17,19-20H2,1-3H3,(H,34,38)(H2,32,33,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262452
(CHEMBL4064109)Show SMILES CC(C)Nc1nc(NCc2cccc(NC(=O)C3CCCN(C)C3)c2)c2cc(ccc2n1)-c1ccccc1 Show InChI InChI=1S/C31H36N6O/c1-21(2)33-31-35-28-15-14-24(23-10-5-4-6-11-23)18-27(28)29(36-31)32-19-22-9-7-13-26(17-22)34-30(38)25-12-8-16-37(3)20-25/h4-7,9-11,13-15,17-18,21,25H,8,12,16,19-20H2,1-3H3,(H,34,38)(H2,32,33,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262457
(CHEMBL4101571)Show SMILES CC(C)Nc1nc(NCc2ccc(NC(=O)C3CCCN(C)C3)cc2)c2cc(ccc2n1)-c1ccccc1 Show InChI InChI=1S/C31H36N6O/c1-21(2)33-31-35-28-16-13-24(23-8-5-4-6-9-23)18-27(28)29(36-31)32-19-22-11-14-26(15-12-22)34-30(38)25-10-7-17-37(3)20-25/h4-6,8-9,11-16,18,21,25H,7,10,17,19-20H2,1-3H3,(H,34,38)(H2,32,33,35,36) | PDB
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
Similars
| Article
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| n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262458
(CHEMBL4073156)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:11.14,wD:8.7,(18.04,-4.15,;16.71,-4.93,;16.71,-6.47,;15.37,-4.16,;14.04,-4.94,;14.05,-6.49,;12.71,-7.26,;12.71,-8.8,;14.04,-9.57,;14.03,-11.11,;15.36,-11.88,;16.7,-11.11,;16.7,-9.57,;15.37,-8.79,;18.03,-11.89,;19.37,-11.13,;19.37,-9.59,;20.7,-11.9,;22.03,-11.13,;23.36,-11.92,;23.35,-13.46,;22.01,-14.22,;22,-15.76,;20.69,-13.44,;11.37,-6.49,;10.05,-7.26,;8.72,-6.49,;8.71,-4.95,;10.05,-4.18,;11.38,-4.95,;12.7,-4.18,;7.39,-7.26,;6.05,-6.49,;4.72,-7.27,;4.72,-8.81,;6.07,-9.57,;7.4,-8.8,)| Show InChI InChI=1S/C30H40N6O/c1-20(2)31-30-34-27-16-11-22(21-8-5-4-6-9-21)18-26(27)28(35-30)32-24-12-14-25(15-13-24)33-29(37)23-10-7-17-36(3)19-23/h4-6,8-9,11,16,18,20,23-25H,7,10,12-15,17,19H2,1-3H3,(H,33,37)(H2,31,32,34,35)/t23?,24-,25- | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262459
(CHEMBL4093843)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2ccc(cc2n1)-c1ccccc1 |r,wU:11.14,wD:8.7,(18.57,-18.93,;17.24,-19.71,;17.25,-21.25,;15.91,-18.94,;14.58,-19.72,;14.58,-21.27,;13.24,-22.04,;13.24,-23.58,;14.58,-24.35,;14.57,-25.88,;15.9,-26.65,;17.23,-25.89,;17.24,-24.35,;15.9,-23.57,;18.56,-26.67,;19.9,-25.9,;19.91,-24.36,;21.23,-26.68,;22.56,-25.91,;23.9,-26.69,;23.89,-28.23,;22.54,-28.99,;22.53,-30.53,;21.22,-28.22,;11.91,-21.27,;10.58,-22.03,;9.25,-21.27,;9.25,-19.72,;10.58,-18.96,;11.91,-19.73,;13.24,-18.95,;7.92,-18.95,;7.92,-17.41,;6.59,-16.64,;5.25,-17.41,;5.26,-18.96,;6.59,-19.72,)| Show InChI InChI=1S/C30H40N6O/c1-20(2)31-30-34-27-18-22(21-8-5-4-6-9-21)11-16-26(27)28(35-30)32-24-12-14-25(15-13-24)33-29(37)23-10-7-17-36(3)19-23/h4-6,8-9,11,16,18,20,23-25H,7,10,12-15,17,19H2,1-3H3,(H,33,37)(H2,31,32,34,35)/t23?,24-,25- | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262472
(CHEMBL4077093)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccccc1F |r,wU:11.14,wD:8.7,(40.95,-3.29,;39.62,-4.07,;39.63,-5.61,;38.28,-3.3,;36.95,-4.08,;36.96,-5.63,;35.62,-6.4,;35.62,-7.94,;36.95,-8.71,;36.95,-10.24,;38.27,-11.01,;39.61,-10.25,;39.62,-8.71,;38.28,-7.93,;40.94,-11.03,;42.28,-10.26,;42.28,-8.72,;43.61,-11.04,;44.94,-10.27,;46.27,-11.05,;46.26,-12.6,;44.92,-13.35,;44.91,-14.89,;43.6,-12.58,;34.29,-5.63,;32.96,-6.39,;31.63,-5.63,;31.63,-4.08,;32.96,-3.32,;34.29,-4.09,;35.62,-3.31,;30.3,-6.4,;30.31,-7.93,;28.98,-8.71,;27.64,-7.94,;27.63,-6.4,;28.97,-5.63,;28.96,-4.09,)| Show InChI InChI=1S/C30H39FN6O/c1-19(2)32-30-35-27-15-10-20(24-8-4-5-9-26(24)31)17-25(27)28(36-30)33-22-11-13-23(14-12-22)34-29(38)21-7-6-16-37(3)18-21/h4-5,8-10,15,17,19,21-23H,6-7,11-14,16,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t21?,22-,23- | PDB
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| PC cid
PC sid
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| Article
PubMed
| n/a | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262473
(CHEMBL4071795)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:11.14,wD:8.7,(40.9,-16.35,;39.57,-17.12,;39.57,-18.66,;38.23,-16.36,;36.9,-17.14,;36.9,-18.69,;35.57,-19.46,;35.57,-21,;36.9,-21.77,;36.89,-23.3,;38.22,-24.07,;39.56,-23.31,;39.56,-21.77,;38.23,-20.99,;40.89,-24.09,;42.22,-23.32,;42.23,-21.78,;43.55,-24.1,;44.89,-23.33,;46.22,-24.11,;46.21,-25.65,;44.87,-26.41,;44.86,-27.95,;43.54,-25.64,;34.23,-18.69,;32.91,-19.45,;31.57,-18.69,;31.57,-17.14,;32.91,-16.37,;34.24,-17.15,;35.56,-16.37,;30.25,-19.46,;30.25,-20.99,;28.93,-21.77,;27.58,-21,;27.58,-19.46,;26.25,-18.69,;28.91,-18.69,)| Show InChI InChI=1S/C30H39FN6O/c1-19(2)32-30-35-27-14-9-21(20-6-4-8-23(31)16-20)17-26(27)28(36-30)33-24-10-12-25(13-11-24)34-29(38)22-7-5-15-37(3)18-22/h4,6,8-9,14,16-17,19,22,24-25H,5,7,10-13,15,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t22?,24-,25- | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 73 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262474
(CHEMBL4082303)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(Cl)c1 |r,wU:11.14,wD:8.7,(63.87,-4.01,;62.54,-4.78,;62.55,-6.32,;61.2,-4.02,;59.87,-4.79,;59.88,-6.34,;58.54,-7.11,;58.54,-8.65,;59.87,-9.42,;59.87,-10.96,;61.19,-11.73,;62.53,-10.97,;62.54,-9.43,;61.2,-8.65,;63.86,-11.74,;65.2,-10.98,;65.21,-9.44,;66.53,-11.75,;67.86,-10.99,;69.19,-11.77,;69.18,-13.31,;67.84,-14.07,;67.83,-15.61,;66.52,-13.29,;57.21,-6.34,;55.88,-7.11,;54.55,-6.35,;54.55,-4.8,;55.88,-4.03,;57.21,-4.8,;58.54,-4.03,;53.22,-7.12,;53.23,-8.65,;51.9,-9.43,;50.56,-8.66,;50.56,-7.12,;49.22,-6.35,;51.89,-6.35,)| Show InChI InChI=1S/C30H39ClN6O/c1-19(2)32-30-35-27-14-9-21(20-6-4-8-23(31)16-20)17-26(27)28(36-30)33-24-10-12-25(13-11-24)34-29(38)22-7-5-15-37(3)18-22/h4,6,8-9,14,16-17,19,22,24-25H,5,7,10-13,15,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t22?,24-,25- | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262475
(CHEMBL4090153)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO |r| Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89+,90-,99-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262481
(CHEMBL4095671)Show InChI InChI=1S/C21H21N5S/c1-14(2)24-21-25-17-12-18(16-6-4-3-5-7-16)27-19(17)20(26-21)23-13-15-8-10-22-11-9-15/h3-12,14H,13H2,1-2H3,(H2,23,24,25,26) | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262482
(CHEMBL4065612)Show InChI InChI=1S/C20H19N5S/c1-2-22-20-24-16-11-17(15-8-4-3-5-9-15)26-18(16)19(25-20)23-13-14-7-6-10-21-12-14/h3-12H,2,13H2,1H3,(H2,22,23,24,25) | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262483
(CHEMBL4083566)Show SMILES CC(C)Nc1nc(NCc2cccc(NC(=O)c3cccnc3)c2)c2cc(ccc2n1)-c1ccccc1 Show InChI InChI=1S/C30H28N6O/c1-20(2)33-30-35-27-14-13-23(22-9-4-3-5-10-22)17-26(27)28(36-30)32-18-21-8-6-12-25(16-21)34-29(37)24-11-7-15-31-19-24/h3-17,19-20H,18H2,1-2H3,(H,34,37)(H2,32,33,35,36) | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262484
(CHEMBL4062309)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2ccccc2n1 |r,wU:11.14,wD:8.7,(16.67,-33.09,;15.34,-33.86,;15.34,-35.4,;14,-33.1,;12.67,-33.87,;12.68,-35.42,;11.34,-36.19,;11.34,-37.73,;12.67,-38.5,;12.67,-40.04,;13.99,-40.81,;15.33,-40.05,;15.33,-38.51,;14,-37.73,;16.66,-40.82,;18,-40.06,;18,-38.52,;19.33,-40.83,;20.66,-40.07,;21.99,-40.85,;21.98,-42.39,;20.64,-43.15,;20.63,-44.69,;19.32,-42.37,;10.01,-35.42,;8.68,-36.19,;7.35,-35.43,;7.34,-33.88,;8.68,-33.11,;10.01,-33.88,;11.34,-33.11,)| Show InChI InChI=1S/C24H36N6O/c1-16(2)25-24-28-21-9-5-4-8-20(21)22(29-24)26-18-10-12-19(13-11-18)27-23(31)17-7-6-14-30(3)15-17/h4-5,8-9,16-19H,6-7,10-15H2,1-3H3,(H,27,31)(H2,25,26,28,29)/t17?,18-,19- | PDB
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| PC cid
PC sid
UniChem
Similars
| Article
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| n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50262485
(CHEMBL4098800)Show SMILES CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccc(F)cc1 |r,wU:11.14,wD:8.7,(41.96,-32.4,;40.63,-33.18,;40.64,-34.72,;39.29,-32.41,;37.96,-33.19,;37.97,-34.74,;36.63,-35.51,;36.63,-37.05,;37.97,-37.82,;37.96,-39.36,;39.28,-40.13,;40.62,-39.36,;40.63,-37.82,;39.29,-37.04,;41.95,-40.14,;43.29,-39.37,;43.3,-37.83,;44.62,-40.15,;45.95,-39.38,;47.28,-40.17,;47.27,-41.71,;45.93,-42.47,;45.92,-44,;44.61,-41.69,;35.3,-34.74,;33.97,-35.51,;32.64,-34.74,;32.64,-33.2,;33.97,-32.43,;35.3,-33.2,;36.63,-32.42,;31.31,-35.51,;29.98,-34.74,;28.65,-35.51,;28.65,-37.06,;27.32,-37.83,;29.99,-37.82,;31.32,-37.05,)| Show InChI InChI=1S/C30H39FN6O/c1-19(2)32-30-35-27-15-8-21(20-6-9-23(31)10-7-20)17-26(27)28(36-30)33-24-11-13-25(14-12-24)34-29(38)22-5-4-16-37(3)18-22/h6-10,15,17,19,22,24-25H,4-5,11-14,16,18H2,1-3H3,(H,34,38)(H2,32,33,35,36)/t22?,24-,25- | PDB
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| PC cid
PC sid
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Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 310 | n/a | n/a | n/a | n/a |
Asubio Pharma Co. Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: iwaki.takehiko.v7@asubio.co.jp.
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in intracellular cGMP accumulation after 30 mins in presence of 1-methyl-... |
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.028
BindingDB Entry DOI: 10.7270/Q279475J |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452451
(CHEMBL4210772)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)(C)CO)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;17.76,-5.49,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;19.63,-10.35,;21.17,-10.35,;21.73,-12.46,;23.06,-11.7,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H37FN6O3/c1-17(15-36)30-26-33-24-12-7-19(18-5-4-6-20(29)13-18)14-23(24)25(34-26)31-21-8-10-22(11-9-21)32-27(38)35-28(2,3)16-37/h4-7,12-14,17,21-22,36-37H,8-11,15-16H2,1-3H3,(H2,32,35,38)(H2,30,31,33,34)/t17-,21-,22+/m1/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452452
(CHEMBL4204379)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)N2CC(O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,wD:12.15,(67.01,-7.35,;67.02,-5.82,;68.34,-5.07,;69.66,-5.85,;65.7,-5.06,;64.37,-5.82,;64.36,-7.36,;63.02,-8.12,;63.01,-9.66,;64.34,-10.44,;65.68,-9.68,;67.01,-10.45,;67,-11.99,;65.66,-12.76,;64.33,-11.98,;68.33,-12.77,;69.66,-12.01,;69.67,-10.49,;70.98,-12.78,;71.36,-14.26,;72.84,-13.88,;74.16,-14.65,;72.45,-12.4,;61.69,-7.34,;60.36,-8.11,;59.02,-7.33,;59.03,-5.79,;60.37,-5.03,;61.7,-5.8,;63.04,-5.04,;57.68,-8.1,;57.68,-9.64,;56.34,-10.4,;55.01,-9.62,;55.02,-8.08,;53.69,-7.31,;56.35,-7.32,)| Show InChI InChI=1S/C27H33FN6O3/c1-16(15-35)29-26-32-24-10-5-18(17-3-2-4-19(28)11-17)12-23(24)25(33-26)30-20-6-8-21(9-7-20)31-27(37)34-13-22(36)14-34/h2-5,10-12,16,20-22,35-36H,6-9,13-15H2,1H3,(H,31,37)(H2,29,30,32,33)/t16-,20-,21-/m1/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452453
(CHEMBL4202512)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)CC |r| Show InChI InChI=1S/C128H205N45O39S2/c1-10-64(7)99-121(209)151-52-94(183)152-66(9)101(189)156-77(36-37-91(130)180)109(197)167-85(56-175)105(193)150-53-96(185)154-78(43-62(3)4)103(191)149-54-97(186)155-89(119(207)164-82(48-92(131)181)114(202)169-86(57-176)116(204)163-81(46-68-25-16-13-17-26-68)113(201)159-74(29-20-40-144-126(136)137)107(195)166-84(123(211)212)47-69-32-34-70(179)35-33-69)60-213-214-61-90(171-118(206)88(59-178)170-117(205)87(58-177)168-108(196)75(30-21-41-145-127(138)139)157-106(194)73(28-19-39-143-125(134)135)158-112(200)79(44-63(5)6)161-102(190)71(129)55-174)120(208)162-80(45-67-23-14-12-15-24-67)104(192)148-50-93(182)147-51-95(184)153-72(27-18-38-142-124(132)133)110(198)173-100(65(8)11-2)122(210)165-83(49-98(187)188)115(203)160-76(111(199)172-99)31-22-42-146-128(140)141/h12-17,23-26,32-35,62-66,71-90,99-100,174-179H,10-11,18-22,27-31,36-61,129H2,1-9H3,(H2,130,180)(H2,131,181)(H,147,182)(H,148,192)(H,149,191)(H,150,193)(H,151,209)(H,152,183)(H,153,184)(H,154,185)(H,155,186)(H,156,189)(H,157,194)(H,158,200)(H,159,201)(H,160,203)(H,161,190)(H,162,208)(H,163,204)(H,164,207)(H,165,210)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,173,198)(H,187,188)(H,211,212)(H4,132,133,142)(H4,134,135,143)(H4,136,137,144)(H4,138,139,145)(H4,140,141,146)/t64-,65-,66-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85+,86-,87-,88-,89-,90-,99-,100-/m0/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452454
(CHEMBL4216406)Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2cnc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.45,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.1,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.12,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H38FN7O3/c1-16(2)25(15-38)35-28(39)33-21-9-7-20(8-10-21)32-26-22-12-23(18-5-4-6-19(29)11-18)30-13-24(22)34-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,20-21,25,37-38H,7-10,14-15H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t17-,20-,21+,25+/m1/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452455
(CHEMBL4215510)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(cnc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,wD:18.21,(16.43,-4.72,;15.1,-5.48,;15.1,-7.02,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;20.42,-10.15,;21.75,-9.39,;19.1,-9.37,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H38FN7O2/c1-16(2)24(15-37)34-28(38)33-22-10-8-21(9-11-22)32-26-23-13-19(18-6-5-7-20(29)12-18)14-30-25(23)35-27(36-26)31-17(3)4/h5-7,12-14,16-17,21-22,24,37H,8-11,15H2,1-4H3,(H2,33,34,38)(H2,30,31,32,35,36)/t21-,22+,24-/m0/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452456
(CHEMBL4206652)Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ncc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H38FN7O3/c1-16(2)24(15-38)34-28(39)33-22-9-7-21(8-10-22)32-26-23-12-19(18-5-4-6-20(29)11-18)13-30-25(23)35-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,21-22,24,37-38H,7-10,14-15H2,1-3H3,(H2,33,34,39)(H2,30,31,32,35,36)/t17-,21-,22+,24+/m1/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452457
(CHEMBL4213559)Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26+/m1/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452458
(CHEMBL4207138)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.02,;15.11,-5.48,;16.44,-4.72,;17.76,-5.49,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;21.63,-10.74,;21.11,-9.29,;19.58,-9.33,;19.14,-10.81,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1 | PDB
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Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452459
(CHEMBL4209646)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(NC(C)C)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,7.6,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;13.79,-4.72,;15.1,-5.48,;15.1,-7.02,;16.43,-4.72,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O/c1-16(2)29-26-33-24-13-8-19(18-6-5-7-20(28)14-18)15-23(24)25(34-26)31-21-9-11-22(12-10-21)32-27(35)30-17(3)4/h5-8,13-17,21-22H,9-12H2,1-4H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+ | PDB
UniProtKB/SwissProt
GoogleScholar
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | 420 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452460
(CHEMBL4218972)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(nc2ccc(cc12)-c1cccc(F)c1)N(C)CCO |r,wU:10.13,7.6,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,;13.79,-4.72,;13.8,-3.18,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)29-27(36)31-22-10-8-21(9-11-22)30-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)32-26(33-25)34(3)13-14-35/h4-7,12,15-17,21-22,35H,8-11,13-14H2,1-3H3,(H2,29,31,36)(H,30,32,33)/t21-,22+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452461
(CHEMBL4214047)Show SMILES COCCNc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)30-27(35)32-22-10-8-21(9-11-22)31-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)33-26(34-25)29-13-14-36-3/h4-7,12,15-17,21-22H,8-11,13-14H2,1-3H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+ | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
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| Article
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| n/a | n/a | n/a | n/a | 610 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452462
(CHEMBL4217505)Show SMILES COC[C@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,wD:3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452463
(CHEMBL4206328)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.11,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.4,-11.69,;20.41,-10.15,;21.75,-9.4,;23.07,-10.18,;23.06,-11.71,;24.38,-12.49,;21.73,-12.46,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H40FN7O2/c1-19(18-39)32-29-36-27-13-8-21(20-5-3-6-22(31)15-20)16-26(27)28(37-29)33-23-9-11-24(12-10-23)34-30(40)35-25-7-4-14-38(2)17-25/h3,5-6,8,13,15-16,19,23-25,39H,4,7,9-12,14,17-18H2,1-2H3,(H2,34,35,40)(H2,32,33,36,37)/t19-,23-,24+,25?/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452464
(CHEMBL4212125)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,7.6,18.19,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;13.79,-4.72,;15.1,-5.48,;15.1,-7.01,;16.43,-4.73,;17.75,-5.51,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.77,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22+/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 74 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452465
(CHEMBL4209251)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,18.19,wD:7.6,(75.48,-29.25,;74.16,-28.48,;74.17,-26.95,;72.83,-29.24,;71.5,-28.47,;71.51,-26.94,;70.17,-29.23,;68.84,-28.45,;68.85,-26.91,;67.52,-26.13,;66.19,-26.89,;66.18,-28.43,;67.51,-29.21,;64.86,-26.12,;64.86,-24.58,;66.2,-23.81,;66.21,-22.27,;67.55,-21.51,;68.86,-22.28,;68.85,-23.8,;70.19,-21.53,;71.51,-22.3,;64.88,-21.5,;63.54,-22.26,;62.21,-21.49,;60.87,-22.25,;60.86,-23.79,;62.2,-24.57,;63.54,-23.8,;59.53,-24.55,;59.52,-26.09,;58.18,-26.85,;56.85,-26.08,;56.86,-24.54,;55.54,-23.77,;58.2,-23.77,)| Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 530 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452466
(CHEMBL4205825)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(45.91,-35.08,;45.92,-33.55,;47.24,-32.8,;48.56,-33.58,;44.6,-32.79,;43.27,-33.55,;43.26,-35.09,;41.92,-35.85,;41.91,-37.39,;43.24,-38.17,;44.58,-37.41,;45.91,-38.18,;45.9,-39.72,;44.56,-40.49,;43.23,-39.71,;47.23,-40.5,;48.56,-39.74,;48.57,-38.22,;49.88,-40.52,;50.26,-41.99,;51.74,-41.61,;53.06,-42.38,;51.35,-40.13,;40.59,-35.07,;39.26,-35.84,;37.92,-35.06,;37.93,-33.52,;39.27,-32.76,;40.6,-33.53,;41.94,-32.77,;36.58,-35.83,;36.57,-37.37,;35.24,-38.13,;33.91,-37.35,;33.92,-35.81,;32.59,-35.04,;35.25,-35.05,)| Show InChI InChI=1S/C28H34FN5O3/c1-16(15-35)30-28-33-25-10-5-18(17-3-2-4-20(29)11-17)14-24(25)26(34-28)31-21-6-8-22(9-7-21)32-27(37)19-12-23(36)13-19/h2-5,10-11,14,16,19,21-23,35-36H,6-9,12-13,15H2,1H3,(H,32,37)(H2,30,31,33,34)/t16-,19-,21-,22-,23-/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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| Article
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| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452467
(CHEMBL4218032)Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1 |r,wU:14.18,22.24,4.3,wD:11.11,6.8,(53.52,-15.72,;52.19,-14.94,;52.21,-13.41,;50.86,-15.7,;49.53,-14.92,;48.05,-15.31,;47.67,-13.83,;49.15,-13.44,;46.35,-13.06,;46.36,-11.53,;45.02,-13.82,;43.69,-13.04,;43.69,-11.49,;42.36,-10.72,;41.02,-11.48,;41.02,-13.02,;42.35,-13.8,;39.69,-10.71,;39.7,-9.16,;41.04,-8.39,;41.05,-6.85,;42.39,-6.09,;43.71,-6.86,;43.7,-8.39,;45.03,-6.1,;46.36,-6.88,;39.72,-6.08,;38.38,-6.84,;37.05,-6.06,;35.7,-6.82,;35.69,-8.37,;37.03,-9.15,;38.37,-8.38,;34.35,-9.14,;34.35,-10.68,;33.01,-11.44,;31.68,-10.66,;31.68,-9.12,;33.02,-8.35,)| Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452454
(CHEMBL4216406)Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2cnc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.45,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.1,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.12,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H38FN7O3/c1-16(2)25(15-38)35-28(39)33-21-9-7-20(8-10-21)32-26-22-12-23(18-5-4-6-19(29)11-18)30-13-24(22)34-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,20-21,25,37-38H,7-10,14-15H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t17-,20-,21+,25+/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | n/a | n/a | 620 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
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