| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1/beta |
|---|
| Ligand | BDBM50232892 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1649354 (CHEMBL3998488) |
|---|
| IC50 | 780±n/a nM |
|---|
| Citation |  Mohsen, AM; Mandour, YM; Sarukhanyan, E; Breitinger, U; Villmann, C; Banoub, MM; Breitinger, HG; Dandekar, T; Holzgrabe, U; Sotriffer, C; Jensen, AA; Zlotos, DP Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists. J Nat Prod79:2997-3005 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycine receptor subunit alpha-1/beta |
|---|
| Name: | Glycine receptor subunit alpha-1/beta |
|---|
| Synonyms: | Glycine receptor (alpha-1/beta) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 2112032 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Glycine receptor subunit alpha-1 |
|---|
| Synonyms: | GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52635.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23415 |
|---|
| Residue: | 457 |
|---|
| Sequence: | MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
|
|
|
|---|
| Component 2 |
| Name: | Glycine receptor subunit beta |
|---|
| Synonyms: | GLRB | GLRB_HUMAN | Glycine receptor 58 kDa subunit | Glycine receptor alpha-3/beta | Glycine receptor subunit beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56135.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_117714 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL
NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS
DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT
LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY
GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP
LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV
EAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDF
SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL
FPFCFLFFNVIYWSIYL
|
|
|
|---|
| BDBM50232892 |
|---|
| n/a |
|---|
| Name | BDBM50232892 |
|---|
| Synonyms: | CHEMBL4066164 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H29N3O3 |
|---|
| Mol. Mass. | 467.5589 |
|---|
| SMILES | [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCCc6ccccc6)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5| |
|---|
| Structure | 
|
|---|
Search and Browse
