Reaction Details |
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Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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Ligand | BDBM50232925 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1649543 (CHEMBL3998677) |
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IC50 | 565±n/a nM |
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Citation | Tso, SC; Lou, M; Wu, CY; Gui, WJ; Chuang, JL; Morlock, LK; Williams, NS; Wynn, RM; Qi, X; Chuang, DT Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. J Med Chem60:1142-1150 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
Type: | Enzyme |
Mol. Mass.: | 46153.78 |
Organism: | Homo sapiens (Human) |
Description: | Q15119 |
Residue: | 407 |
Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
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BDBM50232925 |
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n/a |
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Name | BDBM50232925 |
Synonyms: | CHEMBL4095603 |
Type | Small organic molecule |
Emp. Form. | C27H27N3O7S |
Mol. Mass. | 537.584 |
SMILES | OC(=O)c1ccccc1C(=O)N1CCC(CC1)Nc1ccc2CN(Cc2c1)S(=O)(=O)c1ccc(O)cc1O |
Structure |
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