| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Liver carboxylesterase 1 |
|---|
| Ligand | BDBM50233193 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1649827 (CHEMBL3998961) |
|---|
| Ki | 18±n/a nM |
|---|
| Citation |  Hatfield, MJ; Chen, J; Fratt, EM; Chi, L; Bollinger, JC; Binder, RJ; Bowling, J; Hyatt, JL; Scarborough, J; Jeffries, C; Potter, PM Selective Inhibitors of Human Liver Carboxylesterase Based on aß-Lapachone Scaffold: Novel Reagents for Reaction Profiling. J Med Chem60:1568-1579 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Liver carboxylesterase 1 |
|---|
| Name: | Liver carboxylesterase 1 |
|---|
| Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 62520.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 567 |
|---|
| Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
|
|
|
|---|
| BDBM50233193 |
|---|
| n/a |
|---|
| Name | BDBM50233193 |
|---|
| Synonyms: | CHEMBL4062476 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H15NO3 |
|---|
| Mol. Mass. | 293.3166 |
|---|
| SMILES | COc1ccc(cc1)N(C)C1=CC(=O)C(=O)c2ccccc12 |t:11| |
|---|
| Structure | 
|
|---|
Search and Browse
