Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM50233308 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1650596 (CHEMBL3999730) |
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IC50 | 1685±n/a nM |
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Citation | Wu, S; Sun, Y; Hu, Y; Zhang, H; Hou, L; Liu, X; Li, Y; He, H; Luo, Z; Chen, Y; Wang, Y; Shi, W; Shen, L; Cao, C; Liang, W; Xu, Q; Lv, Q; Lan, J; Li, J; Chen, S Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment. Bioorg Med Chem Lett27:1458-1462 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM50233308 |
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n/a |
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Name | BDBM50233308 |
Synonyms: | CHEMBL4101007 |
Type | Small organic molecule |
Emp. Form. | C24H23N7O |
Mol. Mass. | 425.4857 |
SMILES | [H][C@@]12CN(C[C@]1([H])CN(C2)c1ncnc2ccccc12)C(=O)c1cc(C)ccc1-n1nccn1 |r| |
Structure |
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