| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
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| Ligand | BDBM50233520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1650985 (CHEMBL4000119) |
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| IC50 | >10000±n/a nM |
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| Citation |  Sandham, DA; Barker, L; Brown, L; Brown, Z; Budd, D; Charlton, SJ; Chatterjee, D; Cox, B; Dubois, G; Duggan, N; Hall, E; Hatto, J; Maas, J; Manini, J; Profit, R; Riddy, D; Ritchie, C; Sohal, B; Shaw, D; Stringer, R; Sykes, DA; Thomas, M; Turner, KL; Watson, SJ; West, R; Willard, E; Williams, G; Willis, J Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP ACS Med Chem Lett8:582-586 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP4 subtype |
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| Name: | Prostaglandin E2 receptor EP4 subtype |
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| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 53134.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35408 |
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| Residue: | 488 |
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| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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| BDBM50233520 |
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| n/a |
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| Name | BDBM50233520 |
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| Synonyms: | Fevipiprant | NVP-QAW039 | QAW039 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17F3N2O4S |
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| Mol. Mass. | 426.409 |
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| SMILES | Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O |
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| Structure | 
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