| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
|---|
| Ligand | BDBM50233832 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1651523 (CHEMBL4000778) |
|---|
| IC50 | 10±n/a nM |
|---|
| Citation |  Arnsmann, M; Hanekamp, W; Elfringhoff, AS; Lehr, M Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A Eur J Med Chem125:1107-1114 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytosolic phospholipase A2 |
|---|
| Name: | Cytosolic phospholipase A2 |
|---|
| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 85219.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47712 |
|---|
| Residue: | 749 |
|---|
| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
|
|
|
|---|
| BDBM50233832 |
|---|
| n/a |
|---|
| Name | BDBM50233832 |
|---|
| Synonyms: | CHEMBL1800991 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H37NO5 |
|---|
| Mol. Mass. | 491.6185 |
|---|
| SMILES | CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCC)c3cc(ccc23)C(O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
