| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 2 |
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| Ligand | BDBM50234092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1652078 (CHEMBL4001333) |
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| Ki | >100000±n/a nM |
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| Citation |  Krogsgaard-Larsen, N; Delgar, CG; Koch, K; Brown, PM; Møller, C; Han, L; Huynh, TH; Hansen, SW; Nielsen, B; Bowie, D; Pickering, DS; Kastrup, JS; Frydenvang, K; Bunch, L Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidin J Med Chem60:441-457 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 2 |
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| Name: | Glutamate receptor ionotropic, kainate 2 |
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| Synonyms: | GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102478.61 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_936439 |
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| Residue: | 908 |
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| Sequence: | MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
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| BDBM50234092 |
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| n/a |
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| Name | BDBM50234092 |
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| Synonyms: | CHEMBL4073637 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14ClNO5 |
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| Mol. Mass. | 287.696 |
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| SMILES | Cl.OC(=O)[C@@H]1C[C@H](CN1)Oc1cccc(c1)C(O)=O |r| |
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| Structure | 
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