| Reaction Details |
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 | Report a problem with these data |
| Target | Intestinal-type alkaline phosphatase |
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| Ligand | BDBM50234708 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1653677 (CHEMBL4003043) |
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| IC50 | 4750±n/a nM |
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| Citation |  Miliutina, M; Ejaz, SA; Khan, SU; Iaroshenko, VO; Villinger, A; Iqbal, J; Langer, P Synthesis, alkaline phosphatase inhibition studies and molecular docking of novel derivatives of 4-quinolones. Eur J Med Chem126:408-420 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Intestinal-type alkaline phosphatase |
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| Name: | Intestinal-type alkaline phosphatase |
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| Synonyms: | ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN |
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| Type: | Protein |
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| Mol. Mass.: | 57094.82 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P19111 |
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| Residue: | 533 |
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| Sequence: | MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLG
DGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLC
GVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDA
SVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQD
HTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKA
NELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYAL
GGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHI
MAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
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| BDBM50234708 |
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| n/a |
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| Name | BDBM50234708 |
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| Synonyms: | CHEMBL4082351 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O4 |
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| Mol. Mass. | 414.4532 |
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| SMILES | COc1ccc(cc1)C(C)n1c(cc(=O)c2cc(ccc12)[N+]([O-])=O)-c1ccc(C)cc1 |
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| Structure | 
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