| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone acetyltransferase KAT2B |
|---|
| Ligand | BDBM50234930 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1654184 (CHEMBL4003550) |
|---|
| IC50 | 900±n/a nM |
|---|
| Citation |  Humphreys, PG; Bamborough, P; Chung, CW; Craggs, PD; Gordon, L; Grandi, P; Hayhow, TG; Hussain, J; Jones, KL; Lindon, M; Michon, AM; Renaux, JF; Suckling, CJ; Tough, DF; Prinjha, RK Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem60:695-709 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone acetyltransferase KAT2B |
|---|
| Name: | Histone acetyltransferase KAT2B |
|---|
| Synonyms: | Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 93045.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1502838 |
|---|
| Residue: | 832 |
|---|
| Sequence: | MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
|
|
|
|---|
| BDBM50234930 |
|---|
| n/a |
|---|
| Name | BDBM50234930 |
|---|
| Synonyms: | CHEMBL4070058 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H23N5O |
|---|
| Mol. Mass. | 253.3439 |
|---|
| SMILES | NCCCNCc1ccc(NCCCN)[n+]([O-])c1 |
|---|
| Structure | 
|
|---|
Search and Browse
