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TargetHistone acetyltransferase KAT2A/KAT2B
LigandBDBM50234923
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1654182
Ki 1.4±n/a nM
Citation Humphreys PGBamborough PChung CWCraggs PDGordon LGrandi PHayhow TGHussain JJones KLLindon MMichon AMRenaux JFSuckling CJTough DFPrinjha RK Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem 60:695-709 (2017) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Histone acetyltransferase KAT2A/KAT2B
Name:Histone acetyltransferase KAT2A/KAT2B
Synonyms:GCN5 | GCN5L2 | General control of amino acid synthesis protein 5-like 2 | HGCN5 | Histone acetyltransferase GCN5 | Histone acetyltransferase KAT2A | HsGCN5 | KAT2A | Lysine acetyltransferase 2A | STAF97
Type:PROTEIN
Mol. Mass.:93956.22
Organism:Homo sapiens (Human)
Description:ChEMBL_100876
Residue:837
Sequence:
MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT
GGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKC
NGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE
NLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQ
YKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCH
VPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFL
SMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLS
LDSAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLL
SANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIA
RLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIP
YTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLG
KEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTE
RLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
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  Blast E-value cutoff:
BDBM50234923
n/a
NameBDBM50234923
Synonyms:CHEMBL4069412
TypeSmall organic molecule
Emp. Form.C17H21BrN4O
Mol. Mass.377.279
SMILESCN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
Structure
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