| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 |
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| Ligand | BDBM50234950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654287 (CHEMBL4003653) |
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| IC50 | 28000±n/a nM |
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| Citation |  Incerti, M; Russo, S; Callegari, D; Pala, D; Giorgio, C; Zanotti, I; Barocelli, E; Vicini, P; Vacondio, F; Rivara, S; Castelli, R; Tognolini, M; Lodola, A Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. J Med Chem60:787-796 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 |
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| Name: | Ephrin type-A receptor 2 |
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| Synonyms: | 2.7.10.1 | EPHA2_MOUSE | Eck | Epha2 | Ephrin type-A receptor 2 | Epithelial cell kinase | Myk2 | Sek2 | Tyrosine-protein kinase receptor ECK | Tyrosine-protein kinase receptor MPK-5 | Tyrosine-protein kinase receptor SEK-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108847.01 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117464 |
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| Residue: | 977 |
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| Sequence: | MELRAVGFCLALLWGCALAAAAAQGKEVVLLDFAAMKGELGWLTHPYGKGWDLMQNIMDD
MPIYMYSVCNVVSGDQDNWLRTNWVYREEAERIFIELKFTVRDCNSFPGGASSCKETFNL
YYAESDVDYGTNFQKRQFTKIDTIAPDEITVSSDFEARNVKLNVEERMVGPLTRKGFYLA
FQDIGACVALLSVRVYYKKCPEMLQSLARFPETIAVAVSDTQPLATVAGTCVDHAVVPYG
GEGPLMHCTVDGEWLVPIGQCLCQEGYEKVEDACRACSPGFFKSEASESPCLECPEHTLP
STEGATSCQCEEGYFRAPEDPLSMSCTRPPSAPNYLTAIGMGAKVELRWTAPKDTGGRQD
IVYSVTCEQCWPESGECGPCEASVRYSEPPHALTRTSVTVSDLEPHMNYTFAVEARNGVS
GLVTSRSFRTASVSINQTEPPKVRLEDRSTTSLSVTWSIPVSQQSRVWKYEVTYRKKGDA
NSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSTEGSANMAVIG
GVAVGVVLLLVLAGVGLFIHRRRRNLRARQSSEDVRFSKSEQLKPLKTYVDPHTYEDPNQ
AVLKFTTEIHPSCVARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVD
FLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGM
LRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKI
PIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTP
MDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTS
GSEGVPFRTVSEWLESIKMQQYTEHFMVAGYTAIEKVVQMSNEDIKRIGVRLPGHQKRIA
YSLLGLKDQVNTVGIPI
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| BDBM50234950 |
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| n/a |
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| Name | BDBM50234950 |
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| Synonyms: | CHEMBL4059908 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H52N2O3 |
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| Mol. Mass. | 560.8097 |
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| SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(=O)N[C@H](CC(O)=O)Cc1c[nH]c2ccccc12 |r| |
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| Structure | 
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