Reaction Details |
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Target | Serine/threonine-protein kinase Nek2 |
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Ligand | BDBM50235009 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1654329 (CHEMBL4003695) |
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IC50 | 197000±n/a nM |
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Citation | Xi, JB; Fang, YF; Frett, B; Zhu, ML; Zhu, T; Kong, YN; Guan, FJ; Zhao, Y; Zhang, XW; Li, HY; Ma, ML; Hu, W Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem126:1083-1106 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Nek2 |
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Name: | Serine/threonine-protein kinase Nek2 |
Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
Type: | Enzyme |
Mol. Mass.: | 51776.96 |
Organism: | Homo sapiens (Human) |
Description: | P51955 |
Residue: | 445 |
Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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BDBM50235009 |
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n/a |
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Name | BDBM50235009 |
Synonyms: | CHEMBL4061228 |
Type | Small organic molecule |
Emp. Form. | C29H30F3N5O2 |
Mol. Mass. | 537.576 |
SMILES | CNC(=O)c1ccc(cc1OC(C)c1ccccc1C(F)(F)F)-c1cnc2cc(ccn12)N1CCN(C)CC1 |
Structure |
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