| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 |
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| Ligand | BDBM50235010 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654329 (CHEMBL4003695) |
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| IC50 | 591±n/a nM |
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| Citation |  Xi, JB; Fang, YF; Frett, B; Zhu, ML; Zhu, T; Kong, YN; Guan, FJ; Zhao, Y; Zhang, XW; Li, HY; Ma, ML; Hu, W Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem126:1083-1106 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek2 |
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| Name: | Serine/threonine-protein kinase Nek2 |
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| Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51776.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51955 |
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| Residue: | 445 |
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| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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| BDBM50235010 |
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| n/a |
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| Name | BDBM50235010 |
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| Synonyms: | CHEMBL4062949 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29F3N4O3 |
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| Mol. Mass. | 538.5608 |
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| SMILES | C[C@@H](Oc1cc(ccc1C(N)=O)-c1cnc2cc(OC3CCN(C)CC3)ccn12)c1ccccc1C(F)(F)F |r| |
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| Structure | 
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