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TargetVoltage-gated potassium channel beta subunit Mink/subunit Kv7.1
LigandBDBM50235240
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1655135
IC50 790±n/a nM
Citation Wolkenberg SENolt MBBilodeau MTTrotter BWManley PJKett NRNanda KKWu ZCato MJKane SAKiss LSpencer RHWang JLynch JJRegan CPStump GLLi BWhite RYeh SDinsmore CJLindsley CWHartman GD Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett 27:1062-1069 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
Name:Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
Synonyms:Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK)
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 158552
Components:This complex has 2 components.
Component 1
Name:Voltage-gated potassium channel beta subunit Mink
Synonyms:Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel, IKs
Type:PROTEIN
Mol. Mass.:14676.11
Organism:Homo sapiens (Human)
Description:ChEMBL_1456351
Residue:129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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Component 2
Name:KCNQ (Kv7) potassium channel
Synonyms:Voltage-gated potassium channel subunit Kv7.1
Type:PROTEIN
Mol. Mass.:74739.00
Organism:Homo sapiens (Human)
Description:ChEMBL_1454245
Residue:676
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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BDBM50235240
n/a
NameBDBM50235240
Synonyms:CHEMBL4065169
TypeSmall organic molecule
Emp. Form.C24H21FN4O2S
Mol. Mass.448.513
SMILESCS(=O)(=O)Nc1cccc(n1)[C@@H](C(c1cccnc1)c1cccnc1)c1ccc(F)cc1 |r|
Structure
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