| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily E/KQT member 1 |
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| Ligand | BDBM50235240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1655135 (CHEMBL4004501) |
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| IC50 | 790±n/a nM |
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| Citation |  Wolkenberg, SE; Nolt, MB; Bilodeau, MT; Trotter, BW; Manley, PJ; Kett, NR; Nanda, KK; Wu, Z; Cato, MJ; Kane, SA; Kiss, L; Spencer, RH; Wang, J; Lynch, JJ; Regan, CP; Stump, GL; Li, B; White, R; Yeh, S; Dinsmore, CJ; Lindsley, CW; Hartman, GD Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett27:1062-1069 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily E/KQT member 1 |
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| Name: | Potassium voltage-gated channel subfamily E/KQT member 1 |
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| Synonyms: | Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1 | Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 158552 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Potassium voltage-gated channel subfamily E member 1 |
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| Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 14676.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456351 |
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| Residue: | 129 |
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| Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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| Component 2 |
| Name: | Potassium voltage-gated channel subfamily KQT member 1 |
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| Synonyms: | KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74739.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454245 |
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| Residue: | 676 |
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| Sequence: | MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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| BDBM50235240 |
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| n/a |
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| Name | BDBM50235240 |
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| Synonyms: | CHEMBL4065169 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21FN4O2S |
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| Mol. Mass. | 448.513 |
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| SMILES | CS(=O)(=O)Nc1cccc(n1)[C@@H](C(c1cccnc1)c1cccnc1)c1ccc(F)cc1 |r| |
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| Structure | 
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