Reaction Details |
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Target | Prostaglandin G/H synthase 1 |
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Ligand | BDBM50235317 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1655422 (CHEMBL4004892) |
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IC50 | 8300±n/a nM |
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Citation | Abdelrahman, MH; Youssif, BGM; Abdelgawad, MA; Abdelazeem, AH; Ibrahim, HM; Moustafa, AEGA; Treamblu, L; Bukhari, SNA Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity. Eur J Med Chem127:972-985 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 1 |
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Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
Type: | Protein |
Mol. Mass.: | 68868.60 |
Organism: | Ovis aries (Sheep) |
Description: | n/a |
Residue: | 600 |
Sequence: | MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVR
SNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRR
FLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLML
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
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BDBM50235317 |
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n/a |
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Name | BDBM50235317 |
Synonyms: | CHEMBL4080473 |
Type | Small organic molecule |
Emp. Form. | C21H22ClN3O2 |
Mol. Mass. | 383.871 |
SMILES | CN(C)c1ccc(CCNC(=O)c2nc3ccc(Cl)cc3c(O)c2C)cc1 |
Structure |
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