| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50235359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1655478 (CHEMBL4004948) |
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| IC50 | 0.800000±n/a nM |
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| Citation |  Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem60:1746-1767 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50235359 |
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| n/a |
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| Name | BDBM50235359 |
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| Synonyms: | CHEMBL4088242 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N5O4S |
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| Mol. Mass. | 365.407 |
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| SMILES | CC[C@@H](C)Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc(N)c1C=O |r| |
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| Structure | 
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