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TargetPolycomb protein EED
LigandBDBM50235626
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1657638 (CHEMBL4007108)
Ki 13±n/a nM
Citation Curtin, MLPliushchev, MALi, HQTorrent, MDietrich, JDJakob, CGZhu, HZhao, HWang, YJi, ZClark, RFSarris, KASelvaraju, SShaw, BAlgire, MAHe, YRichardson, PLSweis, RFSun, CChiang, GGMichaelides, MR SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg Med Chem Lett27:1576-1583 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polycomb protein EED
Name:Polycomb protein EED
Synonyms:EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:Protein
Mol. Mass.:50201.68
Organism:Homo sapiens (Human)
Description:O75530
Residue:441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50235626
n/a
NameBDBM50235626
Synonyms:CHEMBL4075197
TypeSmall organic molecule
Emp. Form.C22H25BrFN3
Mol. Mass.430.356
SMILESCN(C)[C@H]1CN(Cc2c(F)cccc2Br)C[C@@H]1c1cn(C)c2ccccc12 |r|
Structure
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