| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(4) dopamine receptor |
|---|
| Ligand | BDBM50236961 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1660540 |
|---|
| Ki | 1.3±n/a nM |
|---|
| Citation |  Möller, D; Banerjee, A; Uzuneser, TC; Skultety, M; Huth, T; Plouffe, B; Hübner, H; Alzheimer, C; Friedland, K; Müller, CP; Bouvier, M; Gmeiner, P Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. J Med Chem60:2908-2929 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(4) dopamine receptor |
|---|
| Name: | D(4) dopamine receptor |
|---|
| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48373.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21917 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
|
|
|
|---|
| BDBM50236961 |
|---|
| n/a |
|---|
| Name | BDBM50236961 |
|---|
| Synonyms: | CHEMBL4063235 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N5O2 |
|---|
| Mol. Mass. | 405.4928 |
|---|
| SMILES | COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
