Reaction Details | |||
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Target | Sodium channel protein type 5 subunit alpha | ||
Ligand | BDBM343208 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1662520 (CHEMBL4012201) | ||
IC50 | 140±n/a nM | ||
Citation | Weiss, MM; Dineen, TA; Marx, IE; Altmann, S; Boezio, A; Bregman, H; Chu-Moyer, M; DiMauro, EF; Feric Bojic, E; Foti, RS; Gao, H; Graceffa, R; Gunaydin, H; Guzman-Perez, A; Huang, H; Huang, L; Jarosh, M; Kornecook, T; Kreiman, CR; Ligutti, J; La, DS; Lin, MJ; Liu, D; Moyer, BD; Nguyen, HN; Peterson, EA; Rose, PE; Taborn, K; Youngblood, BD; Yu, V; Fremeau, RT Sulfonamides as Selective Na J Med Chem60:5969-5989 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 5 subunit alpha | |||
Name: | Sodium channel protein type 5 subunit alpha | ||
Synonyms: | HH1 | SCN5A | SCN5A_HUMAN | Sodium channel alpha subunit | Sodium channel protein type 5 subunit alpha/beta-1/beta-2 | Sodium channel protein type V alpha subunit | Voltage-gated sodium channel subunit alpha Nav1.5 | ||
Type: | Enzyme | ||
Mol. Mass.: | 226908.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14524 | ||
Residue: | 2016 | ||
Sequence: |
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BDBM343208 | |||
n/a | |||
Name | BDBM343208 | ||
Synonyms: | 3-amino-4-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-3-isoxazolyl-7-cinnolinesulfonamide | US9776995, Example 446 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H17ClFN5O4S | ||
Mol. Mass. | 525.939 | ||
SMILES | COc1cc(c(Cl)cc1-c1c(N)nnc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1 |(.67,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;-.67,-3.85,;-.67,-5.39,;-2,-3.08,;-2,-1.54,;-3.33,-.77,;-4.67,-1.54,;-4.67,-3.08,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-3.33,3.85,;-2,3.08,;-2,1.54,;-3.33,.77,;-3.33,5.39,;-4.67,6.16,;-4.67,4.62,;-2,6.16,;-.67,5.39,;.8,5.87,;1.7,4.62,;.8,3.37,;-.67,3.85,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;6,-3.08,;3.33,-3.08,)| | ||
Structure |