| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Ligand | BDBM202798 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1663046 (CHEMBL4012727) |
|---|
| EC50 | 80±n/a nM |
|---|
| Citation |  Nishiguchi, GA; Rico, A; Tanner, H; Aversa, RJ; Taft, BR; Subramanian, S; Setti, L; Burger, MT; Wan, L; Tamez, V; Smith, A; Lou, Y; Barsanti, PA; Appleton, BA; Mamo, M; Tandeske, L; Dix, I; Tellew, JE; Huang, S; Mathews Griner, LA; Cooke, VG; Van Abbema, A; Merritt, H; Ma, S; Gampa, K; Feng, F; Yuan, J; Wang, Y; Haling, JR; Vaziri, S; Hekmat-Nejad, M; Jansen, JM; Polyakov, V; Zang, R; Sethuraman, V; Amiri, P; Singh, M; Lees, E; Shao, W; Stuart, DD; Dillon, MP; Ramurthy, S Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J Med Chem60:4869-4881 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Name: | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 73082.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04049 |
|---|
| Residue: | 648 |
|---|
| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
|---|
| BDBM202798 |
|---|
| n/a |
|---|
| Name | BDBM202798 |
|---|
| Synonyms: | US10245267, Example 145 | US10709712, Example 145 | US9242969, 145 | US9694016, 145 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25F3N4O4 |
|---|
| Mol. Mass. | 502.4856 |
|---|
| SMILES | Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OCCO)c(c1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
