| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50144806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1664112 (CHEMBL4013793) |
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| Ki | 3.4±n/a nM |
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| Citation |  Falsini, M; Squarcialupi, L; Catarzi, D; Varano, F; Betti, M; Di Cesare Mannelli, L; Tenci, B; Ghelardini, C; Tanc, M; Angeli, A; Supuran, CT; Colotta, V 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. J Med Chem60:6428-6439 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50144806 |
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| n/a |
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| Name | BDBM50144806 |
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| Synonyms: | 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione | 7-chloro-3-hydroxyquinazoline-2,4-dione | CHEMBL80594 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H5ClN2O3 |
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| Mol. Mass. | 212.59 |
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| SMILES | On1c(=O)[nH]c2cc(Cl)ccc2c1=O |
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| Structure | 
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