Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarbonic anhydrase 1
LigandBDBM50015184
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664113 (CHEMBL4013794)
Ki 83100±n/a nM
Citation Falsini, M; Squarcialupi, L; Catarzi, D; Varano, F; Betti, M; Di Cesare Mannelli, L; Tenci, B; Ghelardini, C; Tanc, M; Angeli, A; Supuran, CT; Colotta, V 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. J Med Chem60:6428-6439 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 1
Name:Carbonic anhydrase 1
Synonyms:CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:Enzyme
Mol. Mass.:28873.37
Organism:Homo sapiens (Human)
Description:P00915
Residue:261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50015184
n/a
NameBDBM50015184
Synonyms:BENZHYDROXAMIC ACID | BENZOHYDROXAMATE | CHEMBL16300 | N-Hydroxy-benzamide | N-hydroxybenzamide | benzoyl hydroxamic acid
TypeSmall organic molecule
Emp. Form.C7H7NO2
Mol. Mass.137.136
SMILESONC(=O)c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: