| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 1B1 |
|---|
| Ligand | BDBM50239037 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1664953 (CHEMBL4014749) |
|---|
| IC50 | 149±n/a nM |
|---|
| Citation |  Mohd Siddique, MU; McCann, GJ; Sonawane, VR; Horley, N; Gatchie, L; Joshi, P; Bharate, SB; Jayaprakash, V; Sinha, BN; Chaudhuri, B Quinazoline derivatives as selective CYP1B1 inhibitors. Eur J Med Chem130:320-327 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 1B1 |
|---|
| Name: | Cytochrome P450 1B1 |
|---|
| Synonyms: | CP1B1_HUMAN | CYP1B1 | CYPIB1 | Cytochrome P450 1B1 (CYP1B1) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60861.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1474523 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ
|
|
|
|---|
| BDBM50239037 |
|---|
| n/a |
|---|
| Name | BDBM50239037 |
|---|
| Synonyms: | CHEMBL4100866 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H12Cl2N2O2 |
|---|
| Mol. Mass. | 383.227 |
|---|
| SMILES | Clc1ccc(Oc2ccc(cc2)-c2nc3ccccc3c(=O)[nH]2)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
