Ki Summary

Reaction Details

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Target

Sigma non-opioid intracellular receptor 1

Ligand

BDBM50095027

Substrate/Competitor

n/a

87±n/a nM

Comments

PDSP_1172

Citation

Kehne, JH; Baron, BM; Carr, AA; Chaney, SF; Elands, J; Feldman, DJ; Frank, RA; van Giersbergen, PL; McCloskey, TC; Johnson, MP; McCarty, DR; Poirot, M; Senyah, Y; Siegel, BW; Widmaier, C Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther277:968-81 (1996) [PubMed]

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Sigma non-opioid intracellular receptor 1

Name:

Sigma non-opioid intracellular receptor 1

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

25266.54

Organism:

RAT

Description:

Q9R0C9

Residue:

223

Sequence:

MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRY
WAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP

BDBM50095027

n/a

Name

BDBM50095027

Synonyms:

(2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol | (2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol (M 100907) | (2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol(MDL 100907) | (R)-(1-(4-fluorophenethyl)piperidin-4-yl)(2,3-dimethoxyphenyl)methanol | (R)-(2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol | (R)-(2,3-Dimethoxyphenyl)-(1-(2-p-fluorophenylethyl)-piperidine-4-yl)-methanol | (R)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol | CHEMBL74355 | MDL 100907 | MDL-100907

Type

Small organic molecule

Emp. Form.

C22H28FNO3

Mol. Mass.

373.461

SMILES

COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC |r|

Structure