| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2B |
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| Ligand | BDBM21395 |
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| Substrate/Competitor | n/a |
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| Ki | 395±n/a nM |
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| Comments | PDSP_1014 |
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| Citation |  Wainscott, DB; Lucaites, VL; Kursar, JD; Baez, M; Nelson, DL Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences. J Pharmacol Exp Ther276:720-7 (1996) [PubMed] |
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| More Info.: | Get all data from this article |
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| 5-hydroxytryptamine receptor 2B |
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| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 54312.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
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| Residue: | 481 |
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| Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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| BDBM21395 |
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| n/a |
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| Name | BDBM21395 |
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| Synonyms: | 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione | 3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}ethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione | CHEMBL1628637 | CHEMBL51 | Ketanserin | R-41,468 | R-41-468 | R41,468 | [3H]-Ketanserin |
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| Type | radiolabeled ligand |
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| Emp. Form. | C22H22FN3O3 |
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| Mol. Mass. | 395.4268 |
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| SMILES | Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 |
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| Structure | 
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