| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Ligand | BDBM84993 |
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| Substrate/Competitor | n/a |
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| Ki | 22.4±n/a nM |
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| Comments | PDSP_493 |
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| Citation |  Scholze, P; Ebert, V; Sieghart, W Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits. Eur J Pharmacol304:155-62 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Synonyms: | GABA A Alpha4Beta2Gamma2 | GABA A Alpha4Beta3Gamma2 | GABA A Alpha4Gamma2 | GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor alpha-4 subunit | GABA(A) receptor subunit alpha-4 | GABRA4 | GBRA4_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 61648.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GABA A Alpha4Beta2Gamma2 0 HUMAN::P48169 |
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| Residue: | 554 |
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| Sequence: | MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ
EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES
SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG
SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV
YLSKDTMEKSESLM
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| BDBM84993 |
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| n/a |
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| Name | BDBM84993 |
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| Synonyms: | 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one | CGS 20625 | CGS-20625 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N3O2 |
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| Mol. Mass. | 309.3624 |
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| SMILES | COc1ccc(cc1)-n1[nH]c2c3CCCCCc3ncc2c1=O |
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| Structure | 
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