Found 216 hits with Last Name = 'sieghart' and Initial = 'w' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM84956
(2-(4-Methoxy-phenyl)-2,5-dihydro-pyrazolo[4,3-c]qu...)Show InChI InChI=1S/C17H13N3O2/c1-22-12-8-6-11(7-9-12)20-17(21)14-10-18-15-5-3-2-4-13(15)16(14)19-20/h2-10,19H,1H3 | PDB
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| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50017009
(2-Phenyl-2,3a-dihydro-pyrazolo[4,3-c]quinolin-3-on...)Show InChI InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,18H | PDB
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| 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM84993
(5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohep...)Show InChI InChI=1S/C18H19N3O2/c1-23-13-9-7-12(8-10-13)21-18(22)15-11-19-16-6-4-2-3-5-14(16)17(15)20-21/h7-11,20H,2-6H2,1H3 | PDB
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| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM84957
(CGS 9896 | CHEMBL20042)Show InChI InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H | PDB
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| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| PDB
Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50067424
((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)Show SMILES CCOC(=O)c1ncn-2c1[C@@H]1CCCN1C(=O)c1cc(OC)ccc-21 Show InChI InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 | PDB
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| 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50017320
(8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-tria...)Show SMILES CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21 Show InChI InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3 | PDB
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| 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM25877
(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)Show InChI InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3 | PDB
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| 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25877
(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)Show InChI InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3 | PDB
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| 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50243981
(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,15H,1H3 | PDB
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50244035
(Beta CCE | CHEMBL454606 | cid_105078 | ethyl 9H-py...)Show InChI InChI=1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3 | PDB
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| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50244227
(CHEMBL458147 | tert-butyl 7-chloro-4-methyl-5-oxo-...)Show InChI InChI=1S/C16H16ClN3O3/c1-16(2,3)23-15(22)12-13-19(4)14(21)10-7-9(17)5-6-11(10)20(13)8-18-12/h5-8H,1-4H3 | PDB
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| 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50244195
(CHEMBL453251 | ethyl 7-chloro-4-methyl-5-oxo-4,5-d...)Show InChI InChI=1S/C14H12ClN3O3/c1-3-21-14(20)11-12-17(2)13(19)9-6-8(15)4-5-10(9)18(12)7-16-11/h4-7H,3H2,1-2H3 | PDB
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| 0.850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50244262
(CHEMBL471978 | ethyl 7-ethynyl-4-methyl-5-oxo-4,5-...)Show InChI InChI=1S/C16H13N3O3/c1-4-10-6-7-12-11(8-10)15(20)18(3)14-13(16(21)22-5-2)17-9-19(12)14/h1,6-9H,5H2,2-3H3 | PDB
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| 1.68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-2/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM50244261
(5-Methyl-6-oxo-8-trimethylsilanylethynyl-3a,4,5,6-...)Show SMILES CN1CC2N(CN=C2C(=O)OC(C)(C)C)c2ccc(cc2C1=O)C#C[Si](C)(C)C |c:6| Show InChI InChI=1S/C22H29N3O3Si/c1-22(2,3)28-21(27)19-18-13-24(4)20(26)16-12-15(10-11-29(5,6)7)8-9-17(16)25(18)14-23-19/h8-9,12,18H,13-14H2,1-7H3 | PDB
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| 2.61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-4-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049735
(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C[Si](C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H27N3O3Si/c1-22(2,3)28-21(27)19-18-13-24(4)20(26)16-12-15(10-11-29(5,6)7)8-9-17(16)25(18)14-23-19/h8-9,12,14H,13H2,1-7H3 | PDB
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| 2.61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50244261
(5-Methyl-6-oxo-8-trimethylsilanylethynyl-3a,4,5,6-...)Show SMILES CN1CC2N(CN=C2C(=O)OC(C)(C)C)c2ccc(cc2C1=O)C#C[Si](C)(C)C |c:6| Show InChI InChI=1S/C22H29N3O3Si/c1-22(2,3)28-21(27)19-18-13-24(4)20(26)16-12-15(10-11-29(5,6)7)8-9-17(16)25(18)14-23-19/h8-9,12,18H,13-14H2,1-7H3 | PDB
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| 2.61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM26263
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM84956
(2-(4-Methoxy-phenyl)-2,5-dihydro-pyrazolo[4,3-c]qu...)Show InChI InChI=1S/C17H13N3O2/c1-22-12-8-6-11(7-9-12)20-17(21)14-10-18-15-5-3-2-4-13(15)16(14)19-20/h2-10,19H,1H3 | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049738
(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)C#C[Si](C)(C)C Show InChI InChI=1S/C20H23N3O3Si/c1-6-26-20(25)18-17-12-22(2)19(24)15-11-14(9-10-27(3,4)5)7-8-16(15)23(17)13-21-18/h7-8,11,13H,6,12H2,1-5H3 | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | Reactome pathway
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-6-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-4 [36-554]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25877
(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)Show InChI InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3 | PDB
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| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25880
(5-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OCCCCCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)C#C Show InChI InChI=1S/C35H30N6O6/c1-5-22-10-12-26-24(16-22)32(42)38(3)18-28-30(36-20-40(26)28)34(44)46-14-8-7-9-15-47-35(45)31-29-19-39(4)33(43)25-17-23(6-2)11-13-27(25)41(29)21-37-31/h1-2,10-13,16-17,20-21H,7-9,14-15,18-19H2,3-4H3 | PDB
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| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50244195
(CHEMBL453251 | ethyl 7-chloro-4-methyl-5-oxo-4,5-d...)Show InChI InChI=1S/C14H12ClN3O3/c1-3-21-14(20)11-12-17(2)13(19)9-6-8(15)4-5-10(9)18(12)7-16-11/h4-7H,3H2,1-2H3 | PDB
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| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-1-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM84992
(Beta CCP | CAS_123662 | NSC_123662)Show InChI InChI=1S/C15H14N2O2/c1-2-7-19-15(18)13-8-11-10-5-3-4-6-12(10)17-14(11)9-16-13/h3-6,8-9,17H,2,7H2,1H3 | PDB
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| 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2 [29-451]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25885
(3-({12-ethynyl-9-phenyl-2,4,8-triazatricyclo[8.4.0...)Show SMILES O=C(OCCCOC(=O)c1ncn-2c1CN=C(c1ccccc1)c1cc(ccc-21)C#C)c1ncn-2c1CN=C(c1ccccc1)c1cc(ccc-21)C#C |t:16,42| Show InChI InChI=1S/C43H30N6O4/c1-3-28-16-18-34-32(22-28)38(30-12-7-5-8-13-30)44-24-36-40(46-26-48(34)36)42(50)52-20-11-21-53-43(51)41-37-25-45-39(31-14-9-6-10-15-31)33-23-29(4-2)17-19-35(33)49(37)27-47-41/h1-2,5-10,12-19,22-23,26-27H,11,20-21,24-25H2 | PDB
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| 7.40 | -43.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM81951
(CAS_104999 | DMCM | NSC_104999)Show InChI InChI=1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,19H,5H2,1-4H3 | PDB
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| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
GABA A receptor alpha-4/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049735
(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C[Si](C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C22H27N3O3Si/c1-22(2,3)28-21(27)19-18-13-24(4)20(26)16-12-15(10-11-29(5,6)7)8-9-17(16)25(18)14-23-19/h8-9,12,14H,13H2,1-7H3 | PDB
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| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 8.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50244228
(CHEMBL458319 | cyclopropylmethyl 7-chloro-4-methyl...)Show InChI InChI=1S/C16H14ClN3O3/c1-19-14-13(16(22)23-7-9-2-3-9)18-8-20(14)12-5-4-10(17)6-11(12)15(19)21/h4-6,8-9H,2-3,7H2,1H3 | PDB
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| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 10.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM81951
(CAS_104999 | DMCM | NSC_104999)Show InChI InChI=1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,19H,5H2,1-4H3 | PDB
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| 11.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM50017009
(2-Phenyl-2,3a-dihydro-pyrazolo[4,3-c]quinolin-3-on...)Show InChI InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,18H | PDB
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| 11.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25883
(ethyl 12-ethynyl-9-phenyl-2,4,8-triazatricyclo[8.4...)Show SMILES CCOC(=O)c1ncn-2c1CN=C(c1ccccc1)c1cc(ccc-21)C#C |t:12| Show InChI InChI=1S/C22H17N3O2/c1-3-15-10-11-18-17(12-15)20(16-8-6-5-7-9-16)23-13-19-21(22(26)27-4-2)24-14-25(18)19/h1,5-12,14H,4,13H2,2H3 | PDB
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| 13.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25879
(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OCCCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)C#C Show InChI InChI=1S/C33H26N6O6/c1-5-20-8-10-24-22(14-20)30(40)36(3)16-26-28(34-18-38(24)26)32(42)44-12-7-13-45-33(43)29-27-17-37(4)31(41)23-15-21(6-2)9-11-25(23)39(27)19-35-29/h1-2,8-11,14-15,18-19H,7,12-13,16-17H2,3-4H3 | PDB
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PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5
(Homo sapiens (Human)) | BDBM50244263
(7-ethynyl-4-methyl-5-oxo-4,5-dihydroimidazo[1,5-a]...)Show SMILES Cn1c2c(ncn2c2ccc(cc2c1=O)C#C)C(=O)OCCOC(=O)c1ncn2c1n(C)c(=O)c1cc(ccc21)C#C Show InChI InChI=1S/C30H20N6O6/c1-5-17-7-9-21-19(13-17)27(37)33(3)25-23(31-15-35(21)25)29(39)41-11-12-42-30(40)24-26-34(4)28(38)20-14-18(6-2)8-10-22(20)36(26)16-32-24/h1-2,7-10,13-16H,11-12H2,3-4H3 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM25879
(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OCCCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)C#C Show InChI InChI=1S/C33H26N6O6/c1-5-20-8-10-24-22(14-20)30(40)36(3)16-26-28(34-18-38(24)26)32(42)44-12-7-13-45-33(43)29-27-17-37(4)31(41)23-15-21(6-2)9-11-25(23)39(27)19-35-29/h1-2,8-11,14-15,18-19H,7,12-13,16-17H2,3-4H3 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50244228
(CHEMBL458319 | cyclopropylmethyl 7-chloro-4-methyl...)Show InChI InChI=1S/C16H14ClN3O3/c1-19-14-13(16(22)23-7-9-2-3-9)18-8-20(14)12-5-4-10(17)6-11(12)15(19)21/h4-6,8-9H,2-3,7H2,1H3 | PDB
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| 16.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-1-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM50244227
(CHEMBL458147 | tert-butyl 7-chloro-4-methyl-5-oxo-...)Show InChI InChI=1S/C16H16ClN3O3/c1-16(2,3)23-15(22)12-13-19(4)14(21)10-7-9(17)5-6-11(10)20(13)8-18-12/h5-8H,1-4H3 | PDB
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| 17.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-1-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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PubMed
| 18.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-3-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM81951
(CAS_104999 | DMCM | NSC_104999)Show InChI InChI=1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,19H,5H2,1-4H3 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Clinic for Psychiatry
Curated by PDSP Ki Database
| |
Eur J Pharmacol 304: 155-62 (1996)
Article DOI: 10.1016/0014-2999(96)00088-x
BindingDB Entry DOI: 10.7270/Q2HD7T6P |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2
(Homo sapiens (Human)) | BDBM50244262
(CHEMBL471978 | ethyl 7-ethynyl-4-methyl-5-oxo-4,5-...)Show InChI InChI=1S/C16H13N3O3/c1-4-10-6-7-12-11(8-10)15(20)18(3)14-13(16(21)22-5-2)17-9-19(12)14/h1,6-9H,5H2,2-3H3 | PDB
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| 21.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to GABAA alpha-2-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b
BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this
Ligand-Target Pair | |
GABA-A receptor; alpha-2/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM25877
(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)Show InChI InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3 | PDB
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| 21.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description
In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c
BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2 [29-451]/beta-3 [26-473]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM25877
(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)Show InChI InChI=1S/C17H15N3O3/c1-4-11-6-7-13-12(8-11)16(21)19(3)9-14-15(17(22)23-5-2)18-10-20(13)14/h1,6-8,10H,5,9H2,2-3H3 | PDB
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| 21.4 | -40.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
University of Wisconsin-Milwaukee
| Assay Description
The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o... |
Bioorg Med Chem 16: 8853-62 (2008)
Article DOI: 10.1016/j.bmc.2008.08.072
BindingDB Entry DOI: 10.7270/Q2GX48WR |
More data for this
Ligand-Target Pair | |
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