Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-2

Ligand

BDBM85207

Substrate/Competitor

n/a

8750±n/a nM

Comments

PDSP_1773

Citation

Stauderman, KA; Mahaffy, LS; Akong, M; Veliçelebi, G; Chavez-Noriega, LE; Crona, JH; Johnson, EC; Elliott, KJ; Gillespie, A; Reid, RT; Adams, P; Harpold, MM; Corey-Naeve, J Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells. J Pharmacol Exp Ther284:777-89 (1998) [PubMed]

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Neuronal acetylcholine receptor subunit alpha-2

Name:

Neuronal acetylcholine receptor subunit alpha-2

Synonyms:

ACHA2_HUMAN | CHRNA2 | Neuronal acetylcholine receptor; alpha2/beta2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

59759.69

Organism:

Homo sapiens (Human)

Description:

Cholinergic, Nicotinic Alpha2Beta2 0 HUMAN::Q15822

Residue:

529

Sequence:

MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI

BDBM85207

n/a

Name

BDBM85207

Synonyms:

CAS_123990 | NSC_123990 | Suberyldicholine

Type

Small organic molecule

Emp. Form.

C18H38N2O4

Mol. Mass.

346.5042

SMILES

C[N+](C)(C)CCOC(=O)CCCCCCC(=O)OCC[N+](C)(C)C

Structure