Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50061101 |
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Substrate/Competitor | n/a |
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Ki | 102±n/a nM |
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Comments | PDSP_412 |
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Citation | Nishikibe, M; Ohta, H; Okada, M; Ishikawa, K; Hayama, T; Fukuroda, T; Noguchi, K; Saito, M; Kanoh, T; Ozaki, S; Kamei, T; Hara, K; William, D; Kivlighn, S; Krause, S; Gabel, R; Zingaro, G; Nolan, N; O'Brien, J; Clayton, F; Lynch, J; Pettibone, D; Siegl, P Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther289:1262-70 (1999) [PubMed] |
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More Info.: | Get all data from this article |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49664.00 |
Organism: | Homo sapiens (Human) |
Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
Residue: | 442 |
Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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BDBM50061101 |
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n/a |
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Name | BDBM50061101 |
Synonyms: | 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide | 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide | BOSENTAN | CHEMBL957 | p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C27H29N5O6S |
Mol. Mass. | 551.614 |
SMILES | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1 |
Structure |
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