| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Ligand | BDBM16294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Jump dilution assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 0.090±0.01 nM |
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| Comments | extracted |
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| Citation |  Tonge, P; Pan, P Pyridone FabI inhibitors and uses thereof US Patent US10071965 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Synonyms: | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 27989.00 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q6GI75 |
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| Residue: | 256 |
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| Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
|
|
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| BDBM16294 |
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| n/a |
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| Name | BDBM16294 |
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| Synonyms: | 2PP | 5-Ethyl-2-phenoxy-phenol | 5-butyl-2-phenoxylphenol | 5-ethyl-2-phenoxyphenol | AIDS227443 | PT01 | US10071965, Compound PT04 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14O2 |
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| Mol. Mass. | 214.2598 |
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| SMILES | CCc1ccc(Oc2ccccc2)c(O)c1 |
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| Structure | 
|
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