| Reaction Details |
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 | Report a problem with these data |
| Target | Prostanoid IP receptor |
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| Ligand | BDBM23954 |
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| Substrate/Competitor | n/a |
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| Ki | 11±n/a nM |
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| Comments | PDSP_965 |
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| Citation |  Abramovitz M; Adam M; Boie Y; Carrière M; Denis D; Godbout C; Lamontagne S; Rochette C; Sawyer N; Tremblay NM; Belley M; Gallant M; Dufresne C; Gareau Y; Ruel R; Juteau H; Labelle M; Ouimet N; Metters KM The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483:285-93 (2000) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Prostanoid IP receptor |
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| Name: | Prostanoid IP receptor |
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| Synonyms: | PGI receptor | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40968.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The membranes prepared from human platelet were used in binding assay. |
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| Residue: | 386 |
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| Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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| BDBM23954 |
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| n/a |
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| Name | BDBM23954 |
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| Synonyms: | 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoic acid | CHEMBL494 | ILOPROST | Ventavis | [3H]-Iloprost |
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| Type | radiolabeled ligand |
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| Emp. Form. | C22H32O4 |
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| Mol. Mass. | 360.4871 |
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| SMILES | [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O |
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| Structure | 
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