Reaction Details | |||
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Target | Isoform 2 of Histone lysine demethylase PHF8 (2) | ||
Ligand | BDBM276079 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PHF8 Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 5500±n/a nM | ||
Comments | extracted | ||
Citation | Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Isoform 2 of Histone lysine demethylase PHF8 (2) | |||
Name: | Isoform 2 of Histone lysine demethylase PHF8 (2) | ||
Synonyms: | Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 113932.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9UPP1-2 | ||
Residue: | 1024 | ||
Sequence: |
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BDBM276079 | |||
n/a | |||
Name | BDBM276079 | ||
Synonyms: | 2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(5-fluoro-1H-triazol-4-yl)pyridine | US10071984, Example 41 | US10174003, Example 41 | US9896436, Example 41 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H18F2N6O | ||
Mol. Mass. | 408.404 | ||
SMILES | Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1F |(2.23,-3.53,;.74,-3.92,;-.16,-5.17,;-1.63,-4.69,;-1.63,-3.15,;-.16,-2.68,;.23,-1.19,;-.85,-.1,;-.46,1.39,;1.03,1.78,;1.43,3.27,;2.12,.7,;1.72,-.79,;2.81,-1.88,;4.3,-1.48,;5.39,-2.57,;5.79,-4.06,;6.88,-2.97,;-2.96,-2.38,;-2.96,-.84,;-4.3,-.07,;-5.63,-.84,;-5.63,-2.38,;-4.3,-3.15,;-4.3,1.47,;-3.05,2.37,;-3.53,3.84,;-5.07,3.84,;-5.54,2.37,;-6.88,1.6,)| | ||
Structure |