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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific demethylase 2B | ||
| Ligand | BDBM276092 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FBXL10 Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 550±n/a nM | ||
| Comments | extracted | ||
| Citation |  Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific demethylase 2B | |||
| Name: | Lysine-specific demethylase 2B | ||
| Synonyms: | AA 1-650 | CXXC2 | FBL10 | FBXL10 | Homo sapiens lysine demethylase 2B (KDM2B) | JHDM1B | KDM2B | KDM2B_HUMAN | Lysine-specific demethylase 2B | Lysine-specific demethylase 2B (KDM2B) | NDY1 | NM_032590 | PCCX2 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 152658.35 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8NHM5 | ||
| Residue: | 1336 | ||
| Sequence: |
| ||
| BDBM276092 | |||
| n/a | |||
| Name | BDBM276092 | ||
| Synonyms: | 5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazole | US10071984, Example 54 | US10174003, Example 54 | US9896436, Example 54 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H17FN6O | ||
| Mol. Mass. | 364.3763 | ||
| SMILES | Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| | ||
| Structure | 
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