Reaction Details | |||
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Target | Isoform 2 of Histone lysine demethylase PHF8 (2) | ||
Ligand | BDBM276092 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PHF8 Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 5500±n/a nM | ||
Comments | extracted | ||
Citation | Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Isoform 2 of Histone lysine demethylase PHF8 (2) | |||
Name: | Isoform 2 of Histone lysine demethylase PHF8 (2) | ||
Synonyms: | Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 113932.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9UPP1-2 | ||
Residue: | 1024 | ||
Sequence: |
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BDBM276092 | |||
n/a | |||
Name | BDBM276092 | ||
Synonyms: | 5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazole | US10071984, Example 54 | US10174003, Example 54 | US9896436, Example 54 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H17FN6O | ||
Mol. Mass. | 364.3763 | ||
SMILES | Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| | ||
Structure |