| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM81942 |
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| Substrate/Competitor | n/a |
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| Ki | 2.3±n/a nM |
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| Comments | PDSP_1333 |
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| Citation |  Emonds-Alt, X; Proietto, V; Steinberg, R; Oury-Donat, F; Vigé, X; Vilain, P; Naline, E; Daoui, S; Advenier, C; Le Fur, G; Maffrand, JP; Soubrié, P; Pascal, M SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization. J Pharmacol Exp Ther303:1171-9 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK2R_CAVPO | Neurokinin 2 receptor | Neurokinin NK2 | Substance-K receptor | TACR2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45106.00 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK2 TACR2 GUINEA PIG::Q64077 |
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| Residue: | 402 |
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| Sequence: | MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILA
HQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATK
CVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLR
HLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMA
GDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
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| BDBM81942 |
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| n/a |
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| Name | BDBM81942 |
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| Synonyms: | CAS_55582 | NKA | NSC_55582 | Neurokinin alpha | Substance K |
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| Type | Small organic molecule |
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| Emp. Form. | C50H80N14O14S |
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| Mol. Mass. | 1133.321 |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)C)C(N)=O |
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| Structure | 
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