Reaction Details |
| Report a problem with these data |
Target | Substance-K receptor |
---|
Ligand | BDBM86055 |
---|
Substrate/Competitor | n/a |
---|
Ki | 34±n/a nM |
---|
Comments | PDSP_2982 |
---|
Citation | Emonds-Alt, X; Proietto, V; Steinberg, R; Oury-Donat, F; Vigé, X; Vilain, P; Naline, E; Daoui, S; Advenier, C; Le Fur, G; Maffrand, JP; Soubrié, P; Pascal, M SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization. J Pharmacol Exp Ther303:1171-9 (2002) [PubMed] Article |
---|
More Info.: | Get all data from this article |
---|
|
Substance-K receptor |
---|
Name: | Substance-K receptor |
Synonyms: | NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43868.63 |
Organism: | Rattus norvegicus (Rat) |
Description: | Neurokinin NK2 TACR2 Murine::P16610 |
Residue: | 390 |
Sequence: | MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
|
|
|
BDBM86055 |
---|
n/a |
---|
Name | BDBM86055 |
Synonyms: | SSR240600 |
Type | Small organic molecule |
Emp. Form. | C31H35Cl2F6N3O3 |
Mol. Mass. | 682.524 |
SMILES | CC(C)(C1CCN(CCC2(CN(CCO2)C(=O)Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2ccc(Cl)c(Cl)c2)CC1)C(N)=O |
Structure |
|