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TargetSodium-dependent serotonin transporter
LigandBDBM50005247
Substrate/Competitorn/a
Ki 160±n/a nM
CommentsPDSP_3076
Citation Setola, V; Hufeisen, SJ; Grande-Allen, KJ; Vesely, I; Glennon, RA; Blough, B; Rothman, RB; Roth, BL 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol Pharmacol63:1223-9 (2003) [PubMed]  Article
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Sodium-dependent serotonin transporter
Name:Sodium-dependent serotonin transporter
Synonyms:5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:Multi-pass membrane protein
Mol. Mass.:70168.43
Organism:Rattus norvegicus (rat)
Description:P31652
Residue:630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50005247
n/a
NameBDBM50005247
Synonyms:(+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | (-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | (R)-(-)-2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | (S)-(+)-2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | 2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine | 2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine((R)-(-)-MDA) | 3,4-methylenedioxyamphetamine | CHEMBL6731 | MDA | MDA, (R,S) | MDA,R(-) | Tenamfetamine | methylenedioxyamphetamine
TypeSmall organic molecule
Emp. Form.C10H13NO2
Mol. Mass.179.2157
SMILESCC(N)Cc1ccc2OCOc2c1
Structure
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