Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNeuronal acetylcholine receptor subunit alpha-2
LigandBDBM50010588
Substrate/Competitorn/a
Ki>10000±n/a nM
CommentsPDSP_1184
Citation Setola, V; Hufeisen, SJ; Grande-Allen, KJ; Vesely, I; Glennon, RA; Blough, B; Rothman, RB; Roth, BL 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol Pharmacol63:1223-9 (2003) [PubMed]  Article
More Info.:Get all data from this article
 
Neuronal acetylcholine receptor subunit alpha-2
Name:Neuronal acetylcholine receptor subunit alpha-2
Synonyms:ACHA2_HUMAN | CHRNA2 | Neuronal acetylcholine receptor; alpha2/beta2
Type:Enzyme Catalytic Domain
Mol. Mass.:59759.69
Organism:Homo sapiens (Human)
Description:Cholinergic, Nicotinic Alpha2Beta2 0 HUMAN::Q15822
Residue:529
Sequence:
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50010588
n/a
NameBDBM50010588
Synonyms:(RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-Benzodioxol-5-yl)-N-methyl-2-propanamine | 1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine | 3,4-methylenedioxymethamphetamine | CHEMBL43048 | DL-(3,4-Methylenedioxy)methamphetamine | MDMA | N,alpha-dimethyl-1,3-benzodioxole-5-ethanamine | N-Methyl-3,4-methylenedioxyamphetamine | US11767305, Compound MDMA
TypeSmall organic molecule
Emp. Form.C11H15NO2
Mol. Mass.193.2423
SMILESCNC(C)Cc1ccc2OCOc2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: