| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM87027 |
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| Substrate/Competitor | n/a |
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| Ki | 10±n/a nM |
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| Comments | PDSP_8621 |
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| Citation |  Fish, PV; Deur, C; Gan, X; Greene, K; Hoople, D; Mackenny, M; Para, KS; Reeves, K; Ryckmans, T; Stiff, C; Stobie, A; Wakenhut, F; Whitlock, GA Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition. Bioorg Med Chem Lett18:2562-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM87027 |
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| n/a |
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| Name | BDBM87027 |
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| Synonyms: | (R)-2-((R)-(2,3-difluorophenoxy)(phenyl)methyl)morpholine | (S)-2-((S)-(2,3-difluorophenoxy)(phenyl)methyl)morpholine | CAS_44450181 | CAS_44450185 | NSC_44450181 | NSC_44450185 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17F2NO2 |
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| Mol. Mass. | 305.3192 |
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| SMILES | Fc1cccc(OC(C2CNCCO2)c2ccccc2)c1F |
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| Structure | 
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