Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM87024 |
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Substrate/Competitor | n/a |
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Ki | 10±n/a nM |
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Comments | PDSP_8623 |
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Citation | Fish, PV; Deur, C; Gan, X; Greene, K; Hoople, D; Mackenny, M; Para, KS; Reeves, K; Ryckmans, T; Stiff, C; Stobie, A; Wakenhut, F; Whitlock, GA Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition. Bioorg Med Chem Lett18:2562-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM87024 |
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n/a |
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Name | BDBM87024 |
Synonyms: | (R)-2-((R)-(4-fluoro-2-methylphenoxy)(phenyl)methyl)morpholine | (S)-2-((S)-(4-fluoro-2-methylphenoxy)(phenyl)methyl)morpholine | CAS_44450184 | CAS_44450213 | NSC_44450184 | NSC_44450213 |
Type | Small organic molecule |
Emp. Form. | C18H20FNO2 |
Mol. Mass. | 301.3553 |
SMILES | Cc1cc(F)ccc1OC(C1CNCCO1)c1ccccc1 |
Structure |
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